Beta 2 adrenoreceptor Arg16Gly polymorphism, airway responsiveness, lung function and asthma in infants and children

Stephen William Turner, S. Khoo, I. A. Laing, L. J. Palmer, N. A. Gibson, P. J. Rye, L. I. Landau, P. N. Le Souef

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background We have previously reported a relationship between increased airway responsiveness (AR) in infancy and reduced childhood lung function.

Objective The current study aimed to determine whether the Arg16Gly polymorphism of the beta(2) adrenoceptor (beta(2)AR) gene was important to this relationship.

Methods A cohort that initially numbered 253 individuals underwent assessments of AR and lung function aged 1 month, 6 and 11 years; genotyping for polymorphisms of the beta(2)AR was performed.

Results At 1 month of age, the genotype homozygous Arg16 (n = 24) was associated with a mean increase in log dose-response slope (AR) of 0.27 [95% confidence interval (CI) 0.07, 0.49] compared with the genotype homozygous Gly16 (n = 58), P = 0.01. At 11 years of age, the genotype homozygous Arg16 (n = 35) was associated with a mean reduction in the percentage of forced expiratory volume in 1 s of 5.3% [95% CI 0.3, 10.2] compared with the genotype homozygous Gly16 (n = 65), P = 0.03. There was no association between the Arg16Gly polymorphism and atopy or diagnosed asthma. However, nine of 69 individuals with the genotype homozygous Gly16 were admitted to hospital with asthma compared with five out of 111 individuals with the remaining genotypes (P < 0.05).

Conclusion The Arg16Gly polymorphism may be important to the association between increased AR in infancy and reduced lung function in childhood and may also be a determinant of asthma severity in children but not asthma per se.

Original languageEnglish
Pages (from-to)1043-1048
Number of pages5
JournalClinical & experimental allergy
Volume34
DOIs
Publication statusPublished - 2004

Keywords

  • bronchial hyperreactivity
  • genetics
  • infant
  • longitudinal study
  • respiratory function tests
  • BRONCHIAL HYPERRESPONSIVENESS
  • BETA(2) ADRENOCEPTOR
  • RECEPTOR HAPLOTYPES
  • ASSOCIATION
  • METHACHOLINE
  • POPULATION
  • SMOKING
  • GENE
  • ALBUTEROL
  • GENOTYPE

Cite this

Beta 2 adrenoreceptor Arg16Gly polymorphism, airway responsiveness, lung function and asthma in infants and children. / Turner, Stephen William; Khoo, S.; Laing, I. A.; Palmer, L. J.; Gibson, N. A.; Rye, P. J.; Landau, L. I.; Le Souef, P. N.

In: Clinical & experimental allergy, Vol. 34, 2004, p. 1043-1048.

Research output: Contribution to journalArticle

Turner, Stephen William ; Khoo, S. ; Laing, I. A. ; Palmer, L. J. ; Gibson, N. A. ; Rye, P. J. ; Landau, L. I. ; Le Souef, P. N. / Beta 2 adrenoreceptor Arg16Gly polymorphism, airway responsiveness, lung function and asthma in infants and children. In: Clinical & experimental allergy. 2004 ; Vol. 34. pp. 1043-1048.
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abstract = "Background We have previously reported a relationship between increased airway responsiveness (AR) in infancy and reduced childhood lung function.Objective The current study aimed to determine whether the Arg16Gly polymorphism of the beta(2) adrenoceptor (beta(2)AR) gene was important to this relationship.Methods A cohort that initially numbered 253 individuals underwent assessments of AR and lung function aged 1 month, 6 and 11 years; genotyping for polymorphisms of the beta(2)AR was performed.Results At 1 month of age, the genotype homozygous Arg16 (n = 24) was associated with a mean increase in log dose-response slope (AR) of 0.27 [95{\%} confidence interval (CI) 0.07, 0.49] compared with the genotype homozygous Gly16 (n = 58), P = 0.01. At 11 years of age, the genotype homozygous Arg16 (n = 35) was associated with a mean reduction in the percentage of forced expiratory volume in 1 s of 5.3{\%} [95{\%} CI 0.3, 10.2] compared with the genotype homozygous Gly16 (n = 65), P = 0.03. There was no association between the Arg16Gly polymorphism and atopy or diagnosed asthma. However, nine of 69 individuals with the genotype homozygous Gly16 were admitted to hospital with asthma compared with five out of 111 individuals with the remaining genotypes (P < 0.05).Conclusion The Arg16Gly polymorphism may be important to the association between increased AR in infancy and reduced lung function in childhood and may also be a determinant of asthma severity in children but not asthma per se.",
keywords = "bronchial hyperreactivity, genetics, infant, longitudinal study, respiratory function tests, BRONCHIAL HYPERRESPONSIVENESS, BETA(2) ADRENOCEPTOR, RECEPTOR HAPLOTYPES, ASSOCIATION, METHACHOLINE, POPULATION, SMOKING, GENE, ALBUTEROL, GENOTYPE",
author = "Turner, {Stephen William} and S. Khoo and Laing, {I. A.} and Palmer, {L. J.} and Gibson, {N. A.} and Rye, {P. J.} and Landau, {L. I.} and {Le Souef}, {P. N.}",
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T1 - Beta 2 adrenoreceptor Arg16Gly polymorphism, airway responsiveness, lung function and asthma in infants and children

AU - Turner, Stephen William

AU - Khoo, S.

AU - Laing, I. A.

AU - Palmer, L. J.

AU - Gibson, N. A.

AU - Rye, P. J.

AU - Landau, L. I.

AU - Le Souef, P. N.

PY - 2004

Y1 - 2004

N2 - Background We have previously reported a relationship between increased airway responsiveness (AR) in infancy and reduced childhood lung function.Objective The current study aimed to determine whether the Arg16Gly polymorphism of the beta(2) adrenoceptor (beta(2)AR) gene was important to this relationship.Methods A cohort that initially numbered 253 individuals underwent assessments of AR and lung function aged 1 month, 6 and 11 years; genotyping for polymorphisms of the beta(2)AR was performed.Results At 1 month of age, the genotype homozygous Arg16 (n = 24) was associated with a mean increase in log dose-response slope (AR) of 0.27 [95% confidence interval (CI) 0.07, 0.49] compared with the genotype homozygous Gly16 (n = 58), P = 0.01. At 11 years of age, the genotype homozygous Arg16 (n = 35) was associated with a mean reduction in the percentage of forced expiratory volume in 1 s of 5.3% [95% CI 0.3, 10.2] compared with the genotype homozygous Gly16 (n = 65), P = 0.03. There was no association between the Arg16Gly polymorphism and atopy or diagnosed asthma. However, nine of 69 individuals with the genotype homozygous Gly16 were admitted to hospital with asthma compared with five out of 111 individuals with the remaining genotypes (P < 0.05).Conclusion The Arg16Gly polymorphism may be important to the association between increased AR in infancy and reduced lung function in childhood and may also be a determinant of asthma severity in children but not asthma per se.

AB - Background We have previously reported a relationship between increased airway responsiveness (AR) in infancy and reduced childhood lung function.Objective The current study aimed to determine whether the Arg16Gly polymorphism of the beta(2) adrenoceptor (beta(2)AR) gene was important to this relationship.Methods A cohort that initially numbered 253 individuals underwent assessments of AR and lung function aged 1 month, 6 and 11 years; genotyping for polymorphisms of the beta(2)AR was performed.Results At 1 month of age, the genotype homozygous Arg16 (n = 24) was associated with a mean increase in log dose-response slope (AR) of 0.27 [95% confidence interval (CI) 0.07, 0.49] compared with the genotype homozygous Gly16 (n = 58), P = 0.01. At 11 years of age, the genotype homozygous Arg16 (n = 35) was associated with a mean reduction in the percentage of forced expiratory volume in 1 s of 5.3% [95% CI 0.3, 10.2] compared with the genotype homozygous Gly16 (n = 65), P = 0.03. There was no association between the Arg16Gly polymorphism and atopy or diagnosed asthma. However, nine of 69 individuals with the genotype homozygous Gly16 were admitted to hospital with asthma compared with five out of 111 individuals with the remaining genotypes (P < 0.05).Conclusion The Arg16Gly polymorphism may be important to the association between increased AR in infancy and reduced lung function in childhood and may also be a determinant of asthma severity in children but not asthma per se.

KW - bronchial hyperreactivity

KW - genetics

KW - infant

KW - longitudinal study

KW - respiratory function tests

KW - BRONCHIAL HYPERRESPONSIVENESS

KW - BETA(2) ADRENOCEPTOR

KW - RECEPTOR HAPLOTYPES

KW - ASSOCIATION

KW - METHACHOLINE

KW - POPULATION

KW - SMOKING

KW - GENE

KW - ALBUTEROL

KW - GENOTYPE

U2 - 10.1111/j.1365-2222.2004.02001.x

DO - 10.1111/j.1365-2222.2004.02001.x

M3 - Article

VL - 34

SP - 1043

EP - 1048

JO - Clinical & experimental allergy

JF - Clinical & experimental allergy

SN - 0954-7894

ER -