beta-Glucans and Dectin-1

S Vicky Tsoni, Gordon Douglas Brown

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)

Abstract

beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates. The characterization of dectin-1, in particular, has revealed some of the processes involved in beta-glucan sensing, intracellular signaling, and induction of cellular responses and has provided new insights into the role of beta-glucans in immunity and disease. Here we review both beta-glucans and their receptor, dectin-1.
Original languageEnglish
Pages (from-to)45-60
Number of pages16
JournalAnnals of the New York Academy of Sciences
Volume1143
DOIs
Publication statusPublished - Nov 2008

Keywords

  • animals
  • autoimmunity
  • humans
  • ligands
  • membrane proteins
  • models, biological
  • nerve tissue proteins
  • receptors, immunologic
  • signal transduction
  • beta-glucans
  • ß-glucans
  • ß-glucan receptors
  • dectin-1
  • fungi
  • infection
  • inflammation
  • Syk
  • candida
  • cancer
  • signaling
  • innate immunity
  • macrophage
  • dendritic cell
  • TLR

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