beta-Glucans and Dectin-1

S Vicky Tsoni, Gordon Douglas Brown

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates. The characterization of dectin-1, in particular, has revealed some of the processes involved in beta-glucan sensing, intracellular signaling, and induction of cellular responses and has provided new insights into the role of beta-glucans in immunity and disease. Here we review both beta-glucans and their receptor, dectin-1.
Original languageEnglish
Pages (from-to)45-60
Number of pages16
JournalAnnals of the New York Academy of Sciences
Volume1143
DOIs
Publication statusPublished - Nov 2008

Fingerprint

beta-Glucans
Carbohydrates
Immunity
dectin 1
beta-glucan receptor
Induction

Keywords

  • animals
  • autoimmunity
  • humans
  • ligands
  • membrane proteins
  • models, biological
  • nerve tissue proteins
  • receptors, immunologic
  • signal transduction
  • beta-glucans
  • ß-glucans
  • ß-glucan receptors
  • dectin-1
  • fungi
  • infection
  • inflammation
  • Syk
  • candida
  • cancer
  • signaling
  • innate immunity
  • macrophage
  • dendritic cell
  • TLR

Cite this

beta-Glucans and Dectin-1. / Tsoni, S Vicky; Brown, Gordon Douglas.

In: Annals of the New York Academy of Sciences, Vol. 1143, 11.2008, p. 45-60.

Research output: Contribution to journalArticle

@article{32af6d345bc346d09f9c78cc0557b1f9,
title = "beta-Glucans and Dectin-1",
abstract = "beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates. The characterization of dectin-1, in particular, has revealed some of the processes involved in beta-glucan sensing, intracellular signaling, and induction of cellular responses and has provided new insights into the role of beta-glucans in immunity and disease. Here we review both beta-glucans and their receptor, dectin-1.",
keywords = "animals, autoimmunity, humans, ligands, membrane proteins, models, biological, nerve tissue proteins, receptors, immunologic, signal transduction, beta-glucans, {\ss}-glucans, {\ss}-glucan receptors, dectin-1, fungi, infection, inflammation, Syk, candida, cancer, signaling, innate immunity, macrophage, dendritic cell, TLR",
author = "Tsoni, {S Vicky} and Brown, {Gordon Douglas}",
year = "2008",
month = "11",
doi = "10.1196/annals.1443.019",
language = "English",
volume = "1143",
pages = "45--60",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - beta-Glucans and Dectin-1

AU - Tsoni, S Vicky

AU - Brown, Gordon Douglas

PY - 2008/11

Y1 - 2008/11

N2 - beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates. The characterization of dectin-1, in particular, has revealed some of the processes involved in beta-glucan sensing, intracellular signaling, and induction of cellular responses and has provided new insights into the role of beta-glucans in immunity and disease. Here we review both beta-glucans and their receptor, dectin-1.

AB - beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates. The characterization of dectin-1, in particular, has revealed some of the processes involved in beta-glucan sensing, intracellular signaling, and induction of cellular responses and has provided new insights into the role of beta-glucans in immunity and disease. Here we review both beta-glucans and their receptor, dectin-1.

KW - animals

KW - autoimmunity

KW - humans

KW - ligands

KW - membrane proteins

KW - models, biological

KW - nerve tissue proteins

KW - receptors, immunologic

KW - signal transduction

KW - beta-glucans

KW - ß-glucans

KW - ß-glucan receptors

KW - dectin-1

KW - fungi

KW - infection

KW - inflammation

KW - Syk

KW - candida

KW - cancer

KW - signaling

KW - innate immunity

KW - macrophage

KW - dendritic cell

KW - TLR

U2 - 10.1196/annals.1443.019

DO - 10.1196/annals.1443.019

M3 - Article

VL - 1143

SP - 45

EP - 60

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -