Bioactive Diterpene Derivatives from the Marine Sponge Spongionella sp.

Mostafa Rateb, Wael E Houssen , Marc Schumacher, William Thomas Alexander Harrison, Marc Diederich, Rainer Peter Ebel, Marcel Jaspars

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Three new compounds of the rare classes trisnorditerpenes, bisnorditerpenes, and norditerpenes, gracilins J-L (1, 2, 6), and a new diterpene, 3'-norspongiolactone (8), were isolated from the extract of the marine sponge Spongionella sp. using NMR- and bioassay-guided fractionation, in addition to three known gracilins (3-5) as well as the known diterpenoid tetrahydroaplysulphurin-1 (7). The structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The structure of gracilin H (3) was confirmed by single-crystal X-ray analysis. All compounds wore tested for their cytotoxicity and for their potential to inhibit EGF-R tyrosine kinase.

Original languageEnglish
Pages (from-to)1471-1476
Number of pages6
JournalJournal of Natural Products
Volume72
Issue number8
DOIs
Publication statusPublished - Aug 2009

Keywords

  • fertilized starfish eggs
  • epidermal-growth-factor
  • human pancreatic-cancer
  • inhibit cell-division
  • factor receptor
  • Nor-diterpene
  • Gracilin-b
  • furanosesterterpenes
  • overexpression
  • metabolites

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