Abstract
Three new compounds of the rare classes trisnorditerpenes, bisnorditerpenes, and norditerpenes, gracilins J-L (1, 2, 6), and a new diterpene, 3'-norspongiolactone (8), were isolated from the extract of the marine sponge Spongionella sp. using NMR- and bioassay-guided fractionation, in addition to three known gracilins (3-5) as well as the known diterpenoid tetrahydroaplysulphurin-1 (7). The structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The structure of gracilin H (3) was confirmed by single-crystal X-ray analysis. All compounds wore tested for their cytotoxicity and for their potential to inhibit EGF-R tyrosine kinase.
Original language | English |
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Pages (from-to) | 1471-1476 |
Number of pages | 6 |
Journal | Journal of Natural Products |
Volume | 72 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2009 |
Keywords
- fertilized starfish eggs
- epidermal-growth-factor
- human pancreatic-cancer
- inhibit cell-division
- factor receptor
- Nor-diterpene
- Gracilin-b
- furanosesterterpenes
- overexpression
- metabolites