Bioavailability of arsenic in soil: Pilot study results and design considerations

Edward J Stanek III, Edward J Calabrese, Ramond M Barnes, John MC Danku, Ying Zhou, Paul T. Kostecki, Edward Zillioux

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Bioavailability of arsenic (As) from ingested soil is estimated in a two-period experimental study involving 11 subjects/period. In the first period, a 7-day mass-balance study measured As in food/beverages, urine, and stool to estimate bioavailability of As in food and beverages. Food/beverage As bioavailability (percentage ingested that is not in stool samples) is estimated as 91.0% with a 95% confidence interval given by (84.1%, 97.9%). In the second 7-day study period, subjects were placed on an As suppression diet. In the evening of
day 2, each subject ingested a capsule containing 0.63 g of soil, including approximately 111.7 mg of soil-As. The bioavailability estimate of As from food and beverage ingestion during the first 2 days of the second period was 89.7%. Bioavailability of soil-As was estimated over the 5-day period following capsule ingestion, accounting for estimated bioavailability of food/beverage As. Assuming analytic recovery rates of As from combined soil and food/beverage samples are equal, soil-As bioavailability is estimated as 48.7% (95% CI [36.2%, 61.3%]). Relative to bioavailability of As from food/beverage sources, soil-As is estimated to be 54.3% (95% CI [40.3%, 68.4%]) as bioavailable.
Original languageEnglish
Pages (from-to)945-960
Number of pages16
JournalHuman & Experimental Toxicology
Volume29
Issue number11
Early online date17 Mar 2010
DOIs
Publication statusPublished - Nov 2010

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Arsenic
Biological Availability
Soil
Food and Beverages
Soils
Beverages
Capsules
Eating
Nutrition
Urine
Confidence Intervals

Keywords

  • arsenic
  • bioavailability
  • mass-balance studies
  • soil ingestion
  • risk assessment

Cite this

Stanek III, E. J., Calabrese, E. J., Barnes, R. M., Danku, J. MC., Zhou, Y., Kostecki, P. T., & Zillioux, E. (2010). Bioavailability of arsenic in soil: Pilot study results and design considerations. Human & Experimental Toxicology, 29(11), 945-960. https://doi.org/10.1177/0960327110363860

Bioavailability of arsenic in soil : Pilot study results and design considerations. / Stanek III, Edward J; Calabrese, Edward J; Barnes, Ramond M; Danku, John MC; Zhou, Ying; Kostecki, Paul T. ; Zillioux, Edward.

In: Human & Experimental Toxicology, Vol. 29, No. 11, 11.2010, p. 945-960.

Research output: Contribution to journalArticle

Stanek III, EJ, Calabrese, EJ, Barnes, RM, Danku, JMC, Zhou, Y, Kostecki, PT & Zillioux, E 2010, 'Bioavailability of arsenic in soil: Pilot study results and design considerations', Human & Experimental Toxicology, vol. 29, no. 11, pp. 945-960. https://doi.org/10.1177/0960327110363860
Stanek III EJ, Calabrese EJ, Barnes RM, Danku JMC, Zhou Y, Kostecki PT et al. Bioavailability of arsenic in soil: Pilot study results and design considerations. Human & Experimental Toxicology. 2010 Nov;29(11):945-960. https://doi.org/10.1177/0960327110363860
Stanek III, Edward J ; Calabrese, Edward J ; Barnes, Ramond M ; Danku, John MC ; Zhou, Ying ; Kostecki, Paul T. ; Zillioux, Edward. / Bioavailability of arsenic in soil : Pilot study results and design considerations. In: Human & Experimental Toxicology. 2010 ; Vol. 29, No. 11. pp. 945-960.
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