Abstract
Among the different types of cognitive impairment that appear with increasing age, Alzheimer's disease (AD) is rated as the most frequent. Despite intensive research, key questions concerning AD aetiology remain elusive, but it appears that many biochemical events crucial for neuronal communication and synaptic plasticity fail during the course of the disease. The aim of this review is therefore to provide an overview of intracellular cascades involved in AD pathology. For almost all factors, it is a matter of controversy whether their contribution should be considered to be cause or effect. However: intracellular signalling may be crucial-as it is in learning and memory mechanisms-and malfunction of biochemical pathways may be a common denominator in neurodegenerative processes, thus providing new venues for treatment and therapeutic strategies.
| Original language | English |
|---|---|
| Pages (from-to) | 601-616 |
| Number of pages | 16 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 55 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1999 |
Keywords
- Alzheimer
- acetylcholine
- beta-amyloid
- tau
- Ca2+ homeostasis
- oxidative stress
- neurodegeneration
- second messengers
- phosphatases
- kinases
- AMYLOID PRECURSOR PROTEIN
- ABNORMALLY PHOSPHORYLATED-TAU
- POSTMORTEM HUMAN BRAIN
- NICOTINIC ACETYLCHOLINE-RECEPTORS
- ADENYLYL-CYCLASE ACTIVITY
- PAIRED HELICAL FILAMENTS
- KINASE-C-ALPHA
- BETA-PROTEIN
- SIGNAL-TRANSDUCTION
- PHOSPHOLIPASE-C
Cite this
Biochemical dysfunction and memory loss: the case of Alzheimer's dementia. / Roloff, E V ; Platt, B .
In: Cellular and Molecular Life Sciences, Vol. 55, No. 4, 1999, p. 601-616.Research output: Contribution to journal › Literature review
}
TY - JOUR
T1 - Biochemical dysfunction and memory loss: the case of Alzheimer's dementia
AU - Roloff, E V
AU - Platt, B
PY - 1999
Y1 - 1999
N2 - Among the different types of cognitive impairment that appear with increasing age, Alzheimer's disease (AD) is rated as the most frequent. Despite intensive research, key questions concerning AD aetiology remain elusive, but it appears that many biochemical events crucial for neuronal communication and synaptic plasticity fail during the course of the disease. The aim of this review is therefore to provide an overview of intracellular cascades involved in AD pathology. For almost all factors, it is a matter of controversy whether their contribution should be considered to be cause or effect. However: intracellular signalling may be crucial-as it is in learning and memory mechanisms-and malfunction of biochemical pathways may be a common denominator in neurodegenerative processes, thus providing new venues for treatment and therapeutic strategies.
AB - Among the different types of cognitive impairment that appear with increasing age, Alzheimer's disease (AD) is rated as the most frequent. Despite intensive research, key questions concerning AD aetiology remain elusive, but it appears that many biochemical events crucial for neuronal communication and synaptic plasticity fail during the course of the disease. The aim of this review is therefore to provide an overview of intracellular cascades involved in AD pathology. For almost all factors, it is a matter of controversy whether their contribution should be considered to be cause or effect. However: intracellular signalling may be crucial-as it is in learning and memory mechanisms-and malfunction of biochemical pathways may be a common denominator in neurodegenerative processes, thus providing new venues for treatment and therapeutic strategies.
KW - Alzheimer
KW - acetylcholine
KW - beta-amyloid
KW - tau
KW - Ca2+ homeostasis
KW - oxidative stress
KW - neurodegeneration
KW - second messengers
KW - phosphatases
KW - kinases
KW - AMYLOID PRECURSOR PROTEIN
KW - ABNORMALLY PHOSPHORYLATED-TAU
KW - POSTMORTEM HUMAN BRAIN
KW - NICOTINIC ACETYLCHOLINE-RECEPTORS
KW - ADENYLYL-CYCLASE ACTIVITY
KW - PAIRED HELICAL FILAMENTS
KW - KINASE-C-ALPHA
KW - BETA-PROTEIN
KW - SIGNAL-TRANSDUCTION
KW - PHOSPHOLIPASE-C
UR - http://www.scopus.com/inward/record.url?scp=0032898926&partnerID=8YFLogxK
U2 - 10.1007/s000180050318
DO - 10.1007/s000180050318
M3 - Literature review
C2 - 10357230
VL - 55
SP - 601
EP - 616
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 4
ER -