Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat

M P Law, S Osman, R J Davenport, V J Cunningham, V W Pike, P G Camici

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.
Original languageEnglish
Pages (from-to)417-24
Number of pages8
JournalNuclear Medicine and Biology
Volume24
Issue number5
Publication statusPublished - 1997

Fingerprint

Metaraminol
Myocardium
Desipramine
Liver
Radioactivity
Norepinephrine
High Pressure Liquid Chromatography
Kidney
Muscles
Lung
Injections
Brain
3-hydroxyephedrine

Keywords

  • Animals
  • Carbon Radioisotopes
  • Desipramine
  • Dose-Response Relationship, Drug
  • Ephedrine
  • Male
  • Myocardium
  • Rats
  • Rats, Sprague-Dawley
  • Tissue Distribution

Cite this

Law, M. P., Osman, S., Davenport, R. J., Cunningham, V. J., Pike, V. W., & Camici, P. G. (1997). Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat. Nuclear Medicine and Biology, 24(5), 417-24.

Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat. / Law, M P; Osman, S; Davenport, R J; Cunningham, V J; Pike, V W; Camici, P G.

In: Nuclear Medicine and Biology, Vol. 24, No. 5, 1997, p. 417-24.

Research output: Contribution to journalArticle

Law, MP, Osman, S, Davenport, RJ, Cunningham, VJ, Pike, VW & Camici, PG 1997, 'Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat', Nuclear Medicine and Biology, vol. 24, no. 5, pp. 417-24.
Law MP, Osman S, Davenport RJ, Cunningham VJ, Pike VW, Camici PG. Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat. Nuclear Medicine and Biology. 1997;24(5):417-24.
Law, M P ; Osman, S ; Davenport, R J ; Cunningham, V J ; Pike, V W ; Camici, P G. / Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat. In: Nuclear Medicine and Biology. 1997 ; Vol. 24, No. 5. pp. 417-24.
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AU - Davenport, R J

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AU - Pike, V W

AU - Camici, P G

PY - 1997

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AB - Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.

KW - Animals

KW - Carbon Radioisotopes

KW - Desipramine

KW - Dose-Response Relationship, Drug

KW - Ephedrine

KW - Male

KW - Myocardium

KW - Rats

KW - Rats, Sprague-Dawley

KW - Tissue Distribution

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JO - Nuclear Medicine and Biology

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