Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.
|Number of pages||8|
|Journal||Nuclear Medicine and Biology|
|Publication status||Published - 1997|
- Carbon Radioisotopes
- Dose-Response Relationship, Drug
- Rats, Sprague-Dawley
- Tissue Distribution
Law, M. P., Osman, S., Davenport, R. J., Cunningham, V. J., Pike, V. W., & Camici, P. G. (1997). Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat. Nuclear Medicine and Biology, 24(5), 417-24.