Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

Long Ma; Yufeng Li; Lingpei Meng; Hai Deng; Yuyin Li; Qiang Zhang; Aipo Diao

doi:10.1039/C6RA00100A

Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

Long Ma (Corresponding Author), Yufeng Li, Lingpei Meng, Hai Deng, Yuyin Li, Qiang Zhang, Aipo Diao

Chemistry

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Abstract

We discovered and characterised a novel fluorinating enzyme from marine-derived bacterium Streptomyces xinghaiensis, this is the first ever fluorinase unveiled from marine source. It is also the ‘fastest’ fluorinase by far, which promises to be useful for bio-diagnostic and industrial purposes such as PET radiotracer labeling, fluorinated bio-transformation and synthetic biology.

Original language	English
Pages (from-to)	27047-27051
Number of pages	5
Journal	RSC Advances
Volume	32
Issue number	6
Early online date	2 Mar 2016
DOIs	https://doi.org/10.1039/C6RA00100A
Publication status	Published - 2016

Keywords

biofluorination
fluorinase
marine organisms
streptomyces

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/C6RA00100ALicence: CC BY

Biological fluorination from the sea discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. https://creativecommons.org/licenses/by/3.0/
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Cite this

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title = "Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674",

abstract = "We discovered and characterised a novel fluorinating enzyme from marine-derived bacterium Streptomyces xinghaiensis, this is the first ever fluorinase unveiled from marine source. It is also the {\textquoteleft}fastest{\textquoteright} fluorinase by far, which promises to be useful for bio-diagnostic and industrial purposes such as PET radiotracer labeling, fluorinated bio-transformation and synthetic biology.",

keywords = "biofluorination, fluorinase, marine organisms, streptomyces",

author = "Long Ma and Yufeng Li and Lingpei Meng and Hai Deng and Yuyin Li and Qiang Zhang and Aipo Diao",

note = "We thank Prof. David O{\textquoteright}Hagan and Dr Qingzhi Zhang (University of St Andrews, UK) for their helpful discussion and for providing the synthetic 50 -FDA sample. This work is supported by National Natural Science Foundation of China (No. 81503086), a starting funding (No. 20140520) from Tianjin University of Science & Technology, a research funding of “1000 Talents Plan” of Tianjin (to LM) and Foundation of Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education and Tianjin Key Lab of Industrial Microbiology (No. 2015IM106). Open access via RSC Gold 4 Gold. ",

year = "2016",

doi = "10.1039/C6RA00100A",

language = "English",

volume = "32",

pages = "27047--27051",

journal = "RSC Advances",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Biological fluorination from the sea

T2 - discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

AU - Ma, Long

AU - Li, Yufeng

AU - Meng, Lingpei

AU - Deng, Hai

AU - Li, Yuyin

AU - Zhang, Qiang

AU - Diao, Aipo

N1 - We thank Prof. David O’Hagan and Dr Qingzhi Zhang (University of St Andrews, UK) for their helpful discussion and for providing the synthetic 50 -FDA sample. This work is supported by National Natural Science Foundation of China (No. 81503086), a starting funding (No. 20140520) from Tianjin University of Science & Technology, a research funding of “1000 Talents Plan” of Tianjin (to LM) and Foundation of Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education and Tianjin Key Lab of Industrial Microbiology (No. 2015IM106). Open access via RSC Gold 4 Gold.

PY - 2016

Y1 - 2016

N2 - We discovered and characterised a novel fluorinating enzyme from marine-derived bacterium Streptomyces xinghaiensis, this is the first ever fluorinase unveiled from marine source. It is also the ‘fastest’ fluorinase by far, which promises to be useful for bio-diagnostic and industrial purposes such as PET radiotracer labeling, fluorinated bio-transformation and synthetic biology.

AB - We discovered and characterised a novel fluorinating enzyme from marine-derived bacterium Streptomyces xinghaiensis, this is the first ever fluorinase unveiled from marine source. It is also the ‘fastest’ fluorinase by far, which promises to be useful for bio-diagnostic and industrial purposes such as PET radiotracer labeling, fluorinated bio-transformation and synthetic biology.

KW - biofluorination

KW - fluorinase

KW - marine organisms

KW - streptomyces

U2 - 10.1039/C6RA00100A

DO - 10.1039/C6RA00100A

M3 - Article

VL - 32

SP - 27047

EP - 27051

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 6

ER -

Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

Abstract

Keywords

UN SDGs

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