Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

Long Ma (Corresponding Author), Yufeng Li, Lingpei Meng, Hai Deng, Yuyin Li, Qiang Zhang, Aipo Diao

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Abstract

We discovered and characterised a novel fluorinating enzyme from marine-derived bacterium Streptomyces xinghaiensis, this is the first ever fluorinase unveiled from marine source. It is also the ‘fastest’ fluorinase by far, which promises to be useful for bio-diagnostic and industrial purposes such as PET radiotracer labeling, fluorinated bio-transformation and synthetic biology.
Original languageEnglish
Pages (from-to)27047-27051
Number of pages5
JournalRSC Advances
Volume32
Issue number6
Early online date2 Mar 2016
DOIs
Publication statusPublished - 2016

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Keywords

  • biofluorination
  • fluorinase
  • marine organisms
  • streptomyces

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