Abstract
We discovered and characterised a novel fluorinating enzyme from marine-derived bacterium Streptomyces xinghaiensis, this is the first ever fluorinase unveiled from marine source. It is also the ‘fastest’ fluorinase by far, which promises to be useful for bio-diagnostic and industrial purposes such as PET radiotracer labeling, fluorinated bio-transformation and synthetic biology.
| Original language | English |
|---|---|
| Pages (from-to) | 27047-27051 |
| Number of pages | 5 |
| Journal | RSC Advances |
| Volume | 32 |
| Issue number | 6 |
| Early online date | 2 Mar 2016 |
| DOIs | |
| Publication status | Published - 2016 |
Bibliographical note
We thank Prof. David O’Hagan and Dr Qingzhi Zhang (Universityof St Andrews, UK) for their helpful discussion and for
providing the synthetic 50
-FDA sample. This work is supported
by National Natural Science Foundation of China (No.
81503086), a starting funding (No. 20140520) from Tianjin
University of Science & Technology, a research funding of “1000
Talents Plan” of Tianjin (to LM) and Foundation of Key Laboratory
of Industrial Fermentation Microbiology of Ministry of
Education and Tianjin Key Lab of Industrial Microbiology (No.
2015IM106). Open access via RSC Gold 4 Gold.
Keywords
- biofluorination
- fluorinase
- marine organisms
- streptomyces
Access to Document
- Biological fluorination from the sea discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674
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