Biomarkers and novel agents in esophago-gastric cancer: are we making progress?

Asa Dahle-Smith, Russell D Petty

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Esophago-gastric cancer (EGC) provides a formidable healthcare challenge. Conventional chemotherapy provides modest survival benefit in patients with advanced disease especially in the second-line setting. The recent paradigm shift in the oncology community towards targeting growth factor pathways and the immune system using novel targeted agents has now demonstrated clinical utility in EGC, but recent trial results have highlighted the complexity of disease pathogenesis and significant challenges remain. Here, we describe the current role of targeted therapies in EGC, and their corresponding biomarkers. We aim to provide a comprehensive review of the current climate of novel agents and their biomarkers in advanced EGC.

Original languageEnglish
Pages (from-to)1103-1119
Number of pages17
JournalExpert Review of Anticancer Therapy
Volume15
Issue number9
Early online date2 Aug 2015
DOIs
Publication statusPublished - Sep 2015

Keywords

  • biomarkers
  • esophageal cancer
  • gastric cancer
  • targeted agents
  • translational medicine

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