Biosynthesis and fate of endocannabinoids

Maria Grazia Cascio, Pietro Marini

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)

Abstract

Since the discovery of the two cannabinoid receptors, CB1 and CB2, several molecules, commonly defined as endocannabinoids, able to bind to and functionally activate these receptors, have been discovered and characterized. Although the general thought was that the endocannabinoids were mainly derivatives of the n-6 fatty acid arachidonic acid, recent data have shown that also derivatives (ethanolamides) of n-3 fatty acids may be classified as endocannabinoids. Whether the n-3 endocannabinoids follow the same biosynthetic and metabolic routes of the n-6 endocannabinoids is not yet clear and so warrants further investigation. In this review, we describe the primary biosynthetic and metabolic pathways for the two well-established endocannabinoids, anandamide and 2-arachidonoylglycerol.
Original languageEnglish
Title of host publicationEndocanabinoids
Subtitle of host publication Handbook of Experimental Pharmacology
EditorsRoger G. Pertwee
PublisherSpringer-Verlag
Pages39-58
Number of pages10
Volume231
ISBN (Electronic)978-3-319-20825-1
ISBN (Print)978-3-319-20824-4
DOIs
Publication statusPublished - 2015

Publication series

NameHandbook of Experimental Pharmacology
PublisherSpringer
ISSN (Electronic)0171-2004

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  • Cite this

    Cascio, M. G., & Marini, P. (2015). Biosynthesis and fate of endocannabinoids. In R. G. Pertwee (Ed.), Endocanabinoids: Handbook of Experimental Pharmacology (Vol. 231, pp. 39-58). (Handbook of Experimental Pharmacology). Springer-Verlag. https://doi.org/10.1007/978-3-319-20825-1_2.