Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes

Diana Pinto Prata, Gerome Breen, Janet Munro, Maggie Sinclair, Sarah Osborne, Tao Li, Robert Kerwin, David St. Clair, David A. Collier

Research output: Contribution to journalLetter

17 Citations (Scopus)

Abstract

Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play a role in bipolar disorder, and vice versa. In this study we investigated a total of 15 single nucleotide polymorphisms (SNPs), and all possible haplotypes, of genes that have been previously implicated in schizophrenia or bipolar disorder-RGS4, PRODH, COMT and GRK3-in a sample of 213 cases with bipolar affective disorder type 1 and 197 controls from Scotland. We analysed the polymorphisms allele-wise, genotype-wise and, for each gene, haplotype-wise but obtained no result that reached nominal significance (p <0.05) for an association with the disease status. In conclusion, we could not find evidence of association between RGS4, PRODH, COMT and GRK3 genes and bipolar affective disorder 1 in the Scottish population.

Original languageEnglish
Pages (from-to)229-230
Number of pages2
JournalPsychiatric Genetics
Volume16
Issue number6
Publication statusPublished - Dec 2006

Keywords

  • bipolar disorder
  • genetic association
  • single nucleotide polymorphisms
  • case control study
  • rgs4
  • comt
  • prodh
  • grk3
  • SCHIZOPHRENIA
  • 22Q11
  • LOCUS

Cite this

Prata, D. P., Breen, G., Munro, J., Sinclair, M., Osborne, S., Li, T., ... Collier, D. A. (2006). Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. Psychiatric Genetics, 16(6), 229-230.

Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. / Prata, Diana Pinto; Breen, Gerome; Munro, Janet; Sinclair, Maggie; Osborne, Sarah; Li, Tao; Kerwin, Robert; St. Clair, David; Collier, David A.

In: Psychiatric Genetics, Vol. 16, No. 6, 12.2006, p. 229-230.

Research output: Contribution to journalLetter

Prata, DP, Breen, G, Munro, J, Sinclair, M, Osborne, S, Li, T, Kerwin, R, St. Clair, D & Collier, DA 2006, 'Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes' Psychiatric Genetics, vol. 16, no. 6, pp. 229-230.
Prata DP, Breen G, Munro J, Sinclair M, Osborne S, Li T et al. Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. Psychiatric Genetics. 2006 Dec;16(6):229-230.
Prata, Diana Pinto ; Breen, Gerome ; Munro, Janet ; Sinclair, Maggie ; Osborne, Sarah ; Li, Tao ; Kerwin, Robert ; St. Clair, David ; Collier, David A. / Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. In: Psychiatric Genetics. 2006 ; Vol. 16, No. 6. pp. 229-230.
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AU - Prata, Diana Pinto

AU - Breen, Gerome

AU - Munro, Janet

AU - Sinclair, Maggie

AU - Osborne, Sarah

AU - Li, Tao

AU - Kerwin, Robert

AU - St. Clair, David

AU - Collier, David A.

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AB - Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play a role in bipolar disorder, and vice versa. In this study we investigated a total of 15 single nucleotide polymorphisms (SNPs), and all possible haplotypes, of genes that have been previously implicated in schizophrenia or bipolar disorder-RGS4, PRODH, COMT and GRK3-in a sample of 213 cases with bipolar affective disorder type 1 and 197 controls from Scotland. We analysed the polymorphisms allele-wise, genotype-wise and, for each gene, haplotype-wise but obtained no result that reached nominal significance (p <0.05) for an association with the disease status. In conclusion, we could not find evidence of association between RGS4, PRODH, COMT and GRK3 genes and bipolar affective disorder 1 in the Scottish population.

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