Abstract
Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play a role in bipolar disorder, and vice versa. In this study we investigated a total of 15 single nucleotide polymorphisms (SNPs), and all possible haplotypes, of genes that have been previously implicated in schizophrenia or bipolar disorder-RGS4, PRODH, COMT and GRK3-in a sample of 213 cases with bipolar affective disorder type 1 and 197 controls from Scotland. We analysed the polymorphisms allele-wise, genotype-wise and, for each gene, haplotype-wise but obtained no result that reached nominal significance (p <0.05) for an association with the disease status. In conclusion, we could not find evidence of association between RGS4, PRODH, COMT and GRK3 genes and bipolar affective disorder 1 in the Scottish population.
Original language | English |
---|---|
Pages (from-to) | 229-230 |
Number of pages | 2 |
Journal | Psychiatric Genetics |
Volume | 16 |
Issue number | 6 |
Publication status | Published - Dec 2006 |
Keywords
- bipolar disorder
- genetic association
- single nucleotide polymorphisms
- case control study
- rgs4
- comt
- prodh
- grk3
- SCHIZOPHRENIA
- 22Q11
- LOCUS