Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes

Diana Pinto Prata*, Gerome Breen, Janet Munro, Maggie Sinclair, Sarah Osborne, Tao Li, Robert Kerwin, David St. Clair, David A. Collier

*Corresponding author for this work

Research output: Contribution to journalLetter

17 Citations (Scopus)

Abstract

Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play a role in bipolar disorder, and vice versa. In this study we investigated a total of 15 single nucleotide polymorphisms (SNPs), and all possible haplotypes, of genes that have been previously implicated in schizophrenia or bipolar disorder-RGS4, PRODH, COMT and GRK3-in a sample of 213 cases with bipolar affective disorder type 1 and 197 controls from Scotland. We analysed the polymorphisms allele-wise, genotype-wise and, for each gene, haplotype-wise but obtained no result that reached nominal significance (p <0.05) for an association with the disease status. In conclusion, we could not find evidence of association between RGS4, PRODH, COMT and GRK3 genes and bipolar affective disorder 1 in the Scottish population.

Original languageEnglish
Pages (from-to)229-230
Number of pages2
JournalPsychiatric Genetics
Volume16
Issue number6
Publication statusPublished - Dec 2006

Keywords

  • bipolar disorder
  • genetic association
  • single nucleotide polymorphisms
  • case control study
  • rgs4
  • comt
  • prodh
  • grk3
  • SCHIZOPHRENIA
  • 22Q11
  • LOCUS

Cite this

Prata, D. P., Breen, G., Munro, J., Sinclair, M., Osborne, S., Li, T., ... Collier, D. A. (2006). Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. Psychiatric Genetics, 16(6), 229-230.

Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. / Prata, Diana Pinto; Breen, Gerome; Munro, Janet; Sinclair, Maggie; Osborne, Sarah; Li, Tao; Kerwin, Robert; St. Clair, David; Collier, David A.

In: Psychiatric Genetics, Vol. 16, No. 6, 12.2006, p. 229-230.

Research output: Contribution to journalLetter

Prata, DP, Breen, G, Munro, J, Sinclair, M, Osborne, S, Li, T, Kerwin, R, St. Clair, D & Collier, DA 2006, 'Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes', Psychiatric Genetics, vol. 16, no. 6, pp. 229-230.
Prata DP, Breen G, Munro J, Sinclair M, Osborne S, Li T et al. Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. Psychiatric Genetics. 2006 Dec;16(6):229-230.
Prata, Diana Pinto ; Breen, Gerome ; Munro, Janet ; Sinclair, Maggie ; Osborne, Sarah ; Li, Tao ; Kerwin, Robert ; St. Clair, David ; Collier, David A. / Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes. In: Psychiatric Genetics. 2006 ; Vol. 16, No. 6. pp. 229-230.
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T1 - Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes

AU - Prata, Diana Pinto

AU - Breen, Gerome

AU - Munro, Janet

AU - Sinclair, Maggie

AU - Osborne, Sarah

AU - Li, Tao

AU - Kerwin, Robert

AU - St. Clair, David

AU - Collier, David A.

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AB - Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play a role in bipolar disorder, and vice versa. In this study we investigated a total of 15 single nucleotide polymorphisms (SNPs), and all possible haplotypes, of genes that have been previously implicated in schizophrenia or bipolar disorder-RGS4, PRODH, COMT and GRK3-in a sample of 213 cases with bipolar affective disorder type 1 and 197 controls from Scotland. We analysed the polymorphisms allele-wise, genotype-wise and, for each gene, haplotype-wise but obtained no result that reached nominal significance (p <0.05) for an association with the disease status. In conclusion, we could not find evidence of association between RGS4, PRODH, COMT and GRK3 genes and bipolar affective disorder 1 in the Scottish population.

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KW - SCHIZOPHRENIA

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