Birds sacrifice oxidative protection for reproduction

P Wiersma, C Selman, J R Speakman, S Verhulst

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

Oxidative metabolism has reactive oxygen species (ROS) as unavoidable by-products, and the damage ROS inflicts on DNA, proteins and lipids is considered to be a major agent of senescence. Increasing reproductive effort accelerates senescence, but whether reproductive effort is increased at the expense of protection against oxidative damage has not yet been tested. We manipulated reproductive effort in zebra finches through brood size manipulation and measured the activity of two major antioxidant enzymes (superoxide dismutase (SOD) and glutathione peroxidase (GPx)) in the pectoral muscle after 19-20 days of brood rearing. Oxidative stress is reflected by the balance between oxidative protection and ROS exposure, and we therefore scaled SOD and GPx activity to daily energy expenditure (DEE) as an index of ROS production. SOD and GPx activity decreased with increasing brood size by 28% and 24%, respectively. This effect was identical in the two sexes, but arose in different ways: males did not change their DEE, but had lower absolute enzyme activity, and females increased their DEE, but did not change absolute enzyme activity. This result suggests that senescence acceleration by increased reproductive effort is at least in part mediated by oxidative stress.

Original languageEnglish
Number of pages4
JournalProceedings of the Royal Society of London. B, Biological Sciences
Volume271
DOIs
Publication statusPublished - 2004

Keywords

  • antioxidants
  • superoxide dismutase
  • glutathione peroxidase
  • oxidative stress
  • costs of reproduction
  • Taeniopygia guttata
  • brood size
  • stress
  • damage
  • overexpression
  • manipulations
  • senescence
  • survival
  • biology
  • age

Cite this

Birds sacrifice oxidative protection for reproduction. / Wiersma, P ; Selman, C ; Speakman, J R ; Verhulst, S .

In: Proceedings of the Royal Society of London. B, Biological Sciences, Vol. 271, 2004.

Research output: Contribution to journalArticle

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