Birth after human chorionic gonadotropin-primed oocyte in vitro maturation and fertilization with testicular sperm in a normo-ovulatory patient

Claudia González-Ortega, Raul Eduardo Pina Aguilar, Patricia Cancino-Villareal, Antonio Martin Gutiérrez-Gutiérrez

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2 Citations (Scopus)


In this report, we present a case of in vitro maturation (IVM) with surgical retrieved testicular sperm in a normo-ovulatory female. Human chorionic gonadotropin-primed IVM, testicular biopsy for sperm retrieval and intracytoplasmic sperm injection with fresh sperm were performed. Fourteen cumulus-oocyte complexes were obtained in germinal vesicle or metaphase I stage, eight oocytes reached metaphase II, seven presumptive zygotes were obtained, and three cleavage stages embryos in day 2 were transferred producing a singleton pregnancy. A single healthy newborn was obtained. Our results suggest that IVM may be an alternative for in vitro fertilization in normo-ovulatory women even if surgical retrieval of sperm is needed. Further research is required to depict contributing factors to the success of IVM in indications different from polycystic ovaries syndrome and the role of male gamete.

Original languageEnglish
Pages (from-to)210-212
Number of pages3
JournalJournal of Human Reproductive Sciences
Issue number3
Early online date12 Oct 2016
Publication statusPublished - 3 Nov 2016



  • Azoospermia
  • germinal vesicle
  • in vitro maturation
  • intracytoplasmic sperm injection
  • mild approach
  • surgical retrieval of sperm

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