TY - JOUR
T1 - Birth month and infant gross motor development
T2 - Results from the Japan Environment and Children’s Study
AU - Yasumitsu-Lovell, Kahoko
AU - Thompson, Lucy
AU - Fernell, Elisabeth
AU - Eitoku, Masamitsu
AU - Suganuma, Narufumi
AU - Gillberg, Christopher
AU - Japan Environment and Children’s Study Group
N1 - Funding: The Japan Environment and Children’s Study is funded by the Ministry of the Environment, Japan.
Acknowledgments
The authors are grateful to all of the JECS participants; all individuals involved in data collection; the Japan Environment and Children’s Study Group (See Appendix); Nagamasa Maeda, Mikiya Fujieda, Naomi Mitsuda, Atsuko Mori, and Naw Awn J-P of the Kochi Regional Centre of the JECS; and Sifa Marie Joelle Muchanga of the National Center for Global Health and Medicine. The findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of the Ministry of the Environment, Japan.
Members of the JECS Group as of 2021: Michihiro Kamijima (principal investigator, Nagoya City University, Nagoya, Japan), Shin Yamazaki (National Institute for Environmental Studies, Tsukuba, Japan), Yukihiro Ohya (National Center for Child Health and Development, Tokyo, Japan), Reiko Kishi (Hokkaido University, Sapporo, Japan), Nobuo Yaegashi (Tohoku University, Sendai, Japan), Koichi Hashimoto (Fukushima Medical University, Fukushima, Japan), Chisato Mori (Chiba University, Chiba, Japan), Shuichi Ito (Yokohama City Univer- sity, Yokohama, Japan), Zentaro Yamagata (University of Yamanashi, Chuo, Japan), Hidekuni Inadera (University of Toyama, Toyama, Japan), Takeo Nakayama (Kyoto University, Kyoto, Japan), Hiroyasu Iso (Osaka University, Suita, Japan), Masayuki Shima (Hyogo College of Medicine, Nishinomiya, Japan), Youichi Kurozawa (Tottori University, Yonago, Japan), Naru- fumi Suganuma (Kochi University, Nankoku, Japan), Koichi Kusuhara (University of Occupa- tional and Environmental Health, Kitakyushu, Japan), and Takahiko Katoh (Kumamoto University, Kumamoto, Japan).
PY - 2021/4/29
Y1 - 2021/4/29
N2 - The association between birth month and neurodevelopmental or psychiatric disorders has been investigated in a number of previous studies; however, the results have been inconsis- tent. This study investigated the association between birth month and child gross motor development at 6 and 12 months of age in a large cohort of infants (n = 72,203) participating in the Japan Environment and Children’s Study (JECS). Gross motor development was assessed using the Ages and Stages Questionnaire (ASQ-3). At 6 months and 12 months, 20.7% and 14.2%, respectively, had ASQ-3 indications of gross motor problems. Birth month was strongly associated with gross motor development at both time points, particu- larly at 6 months. Summer-born infants had the worst outcomes at both 6 months and 12 months of age. This outcome applied to the ASQ-3 score itself and to the adjusted Relative Risk (aRR), with the highest aRRs (relative to January-born) among August-born (aRR 2.51; 95%CI 2.27–2.78 at 6 months), and June-born (aRR 1.84; 95%CI 1.63–2.09 at 12 months). Boys had better scores than girls both at 6 and 12 months of age. We speculate that seasonal factors—such as maternal vitamin D deficiency and influenza infection— affecting the fetus in early pregnancy might account for the findings.
AB - The association between birth month and neurodevelopmental or psychiatric disorders has been investigated in a number of previous studies; however, the results have been inconsis- tent. This study investigated the association between birth month and child gross motor development at 6 and 12 months of age in a large cohort of infants (n = 72,203) participating in the Japan Environment and Children’s Study (JECS). Gross motor development was assessed using the Ages and Stages Questionnaire (ASQ-3). At 6 months and 12 months, 20.7% and 14.2%, respectively, had ASQ-3 indications of gross motor problems. Birth month was strongly associated with gross motor development at both time points, particu- larly at 6 months. Summer-born infants had the worst outcomes at both 6 months and 12 months of age. This outcome applied to the ASQ-3 score itself and to the adjusted Relative Risk (aRR), with the highest aRRs (relative to January-born) among August-born (aRR 2.51; 95%CI 2.27–2.78 at 6 months), and June-born (aRR 1.84; 95%CI 1.63–2.09 at 12 months). Boys had better scores than girls both at 6 and 12 months of age. We speculate that seasonal factors—such as maternal vitamin D deficiency and influenza infection— affecting the fetus in early pregnancy might account for the findings.
U2 - 10.1371/journal.pone.0251581
DO - 10.1371/journal.pone.0251581
M3 - Article
VL - 16
JO - PloS ONE
JF - PloS ONE
SN - 1932-6203
IS - 5
M1 - e0251581
ER -