Blood antioxidants and indices of lipid peroxidation in subjects with angina pectoris

G G Duthie, J A G Beattie, J R Arthur, M Franklin, P C Morrice, W P T James

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We tested the antioxidant hypothesis of coronary heart disease (CHD) by comparing blood antioxidants, indices of lipid peroxidation and classic (CHD) risk factors of 25 subjects with stable angina pectoris with 200 matched controls. Angina subjects had significantly increased plasma concentrations of total cholesterol, low density lipoproteins and triglycerides although body mass index, plasma cotinine concentration and blood pressure were similar to those of the control group. Plasma concentrations of vitamin A, vitamin C and cholesterol-adjusted vitamin E did not differ between the groups although subjects with angina had significantly decreased plasma uric acid concentrations and elevated indices of lipid peroxidation. Although the results are compatible with the antioxidant hypothesis, it is unclear whether the increased oxidative stress in angina sufferers is a cause or consequence of the disease.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalNutrition
Volume10
Issue number4
Publication statusPublished - Jul 1994

Keywords

  • angina pectoris
  • free radicals
  • lipid peroxidation
  • antioxidants
  • classic risk factors
  • cross-cultural epidemiology
  • low-density-lipoprotein
  • ischemic-heart-disease
  • plasma vitamin-E
  • alpha-tocopherol
  • British men
  • mortality
  • supplementation
  • oxidation
  • pressure

Cite this

Duthie, G. G., Beattie, J. A. G., Arthur, J. R., Franklin, M., Morrice, P. C., & James, W. P. T. (1994). Blood antioxidants and indices of lipid peroxidation in subjects with angina pectoris. Nutrition, 10(4), 313-316.

Blood antioxidants and indices of lipid peroxidation in subjects with angina pectoris. / Duthie, G G; Beattie, J A G; Arthur, J R; Franklin, M; Morrice, P C; James, W P T.

In: Nutrition, Vol. 10, No. 4, 07.1994, p. 313-316.

Research output: Contribution to journalArticle

Duthie, GG, Beattie, JAG, Arthur, JR, Franklin, M, Morrice, PC & James, WPT 1994, 'Blood antioxidants and indices of lipid peroxidation in subjects with angina pectoris', Nutrition, vol. 10, no. 4, pp. 313-316.
Duthie, G G ; Beattie, J A G ; Arthur, J R ; Franklin, M ; Morrice, P C ; James, W P T. / Blood antioxidants and indices of lipid peroxidation in subjects with angina pectoris. In: Nutrition. 1994 ; Vol. 10, No. 4. pp. 313-316.
@article{c12eb13cd401472bb1f855f341a09724,
title = "Blood antioxidants and indices of lipid peroxidation in subjects with angina pectoris",
abstract = "We tested the antioxidant hypothesis of coronary heart disease (CHD) by comparing blood antioxidants, indices of lipid peroxidation and classic (CHD) risk factors of 25 subjects with stable angina pectoris with 200 matched controls. Angina subjects had significantly increased plasma concentrations of total cholesterol, low density lipoproteins and triglycerides although body mass index, plasma cotinine concentration and blood pressure were similar to those of the control group. Plasma concentrations of vitamin A, vitamin C and cholesterol-adjusted vitamin E did not differ between the groups although subjects with angina had significantly decreased plasma uric acid concentrations and elevated indices of lipid peroxidation. Although the results are compatible with the antioxidant hypothesis, it is unclear whether the increased oxidative stress in angina sufferers is a cause or consequence of the disease.",
keywords = "angina pectoris, free radicals, lipid peroxidation, antioxidants, classic risk factors, cross-cultural epidemiology, low-density-lipoprotein, ischemic-heart-disease, plasma vitamin-E, alpha-tocopherol, British men, mortality, supplementation, oxidation, pressure",
author = "Duthie, {G G} and Beattie, {J A G} and Arthur, {J R} and M Franklin and Morrice, {P C} and James, {W P T}",
year = "1994",
month = "7",
language = "English",
volume = "10",
pages = "313--316",
journal = "Nutrition",
issn = "0899-9007",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Blood antioxidants and indices of lipid peroxidation in subjects with angina pectoris

AU - Duthie, G G

AU - Beattie, J A G

AU - Arthur, J R

AU - Franklin, M

AU - Morrice, P C

AU - James, W P T

PY - 1994/7

Y1 - 1994/7

N2 - We tested the antioxidant hypothesis of coronary heart disease (CHD) by comparing blood antioxidants, indices of lipid peroxidation and classic (CHD) risk factors of 25 subjects with stable angina pectoris with 200 matched controls. Angina subjects had significantly increased plasma concentrations of total cholesterol, low density lipoproteins and triglycerides although body mass index, plasma cotinine concentration and blood pressure were similar to those of the control group. Plasma concentrations of vitamin A, vitamin C and cholesterol-adjusted vitamin E did not differ between the groups although subjects with angina had significantly decreased plasma uric acid concentrations and elevated indices of lipid peroxidation. Although the results are compatible with the antioxidant hypothesis, it is unclear whether the increased oxidative stress in angina sufferers is a cause or consequence of the disease.

AB - We tested the antioxidant hypothesis of coronary heart disease (CHD) by comparing blood antioxidants, indices of lipid peroxidation and classic (CHD) risk factors of 25 subjects with stable angina pectoris with 200 matched controls. Angina subjects had significantly increased plasma concentrations of total cholesterol, low density lipoproteins and triglycerides although body mass index, plasma cotinine concentration and blood pressure were similar to those of the control group. Plasma concentrations of vitamin A, vitamin C and cholesterol-adjusted vitamin E did not differ between the groups although subjects with angina had significantly decreased plasma uric acid concentrations and elevated indices of lipid peroxidation. Although the results are compatible with the antioxidant hypothesis, it is unclear whether the increased oxidative stress in angina sufferers is a cause or consequence of the disease.

KW - angina pectoris

KW - free radicals

KW - lipid peroxidation

KW - antioxidants

KW - classic risk factors

KW - cross-cultural epidemiology

KW - low-density-lipoprotein

KW - ischemic-heart-disease

KW - plasma vitamin-E

KW - alpha-tocopherol

KW - British men

KW - mortality

KW - supplementation

KW - oxidation

KW - pressure

M3 - Article

VL - 10

SP - 313

EP - 316

JO - Nutrition

JF - Nutrition

SN - 0899-9007

IS - 4

ER -