Abstract
Background: Blood oxygen level-dependent (BOLD) MRI relies on changes in deoxyhaemoglobin level in tissues under stress for signal variation and may be used for detection of ischaemic myocardium.
Methods: 15 patients with stress induced myocardial ischaemia on PET scanning underwent rest and dypiridamole stress MRI using a double breath-hold T2*-weighted, ECG gated sequence to produce BOLD contrast images and cine-MRI for wall thickening assessment. Signal change on BOLD MRI and wall thickening were compared between rest and stress images in ischaemic and non-ischaemic myocardial segments.
Results: Using PET, 156 segments were identified with reversible ischaemia and 324 as non-ischaemic. The ischaemic segments were found on BOLD MRI to have an average signal change between rest and stress of -16.7% compared to -14% in the non-ischaemic segments (p=0.04). The average wall thickening was 7.8 mm in the ischaemic segments compared with 9.5 mm in the non-ischaemic segments (p < 0.0001).
Conclusion: BOLD MRI with wall thickening assessment may differentiate ischaemic from non-ischaemic myocardium in patients with stress induced myocardial ischaemia. Larger studies with improved spatial resolution would help define a threshold for detection of ischaemia as well as determine this technique's sensitivity and specificity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Original language | English |
---|---|
Pages (from-to) | 36-41 |
Number of pages | 6 |
Journal | International Journal of Cardiology |
Volume | 115 |
Issue number | 1 |
Early online date | 7 Jul 2006 |
DOIs | |
Publication status | Published - 31 Jan 2007 |
Keywords
- bold MRI
- PET
- ischaemia
- perfusion
- N-13 ammonia
- myocardium
- flow
- MRI
- dipyridamole
- stress
- heart
- T-2