Blood pressure in relation to birth weight in twins and singleton controls matched for gestational age

Geraldine McNeill, Chuluuntulga Tuya, Doris Margaret Campbell, Paul Haggarty, William Cairns Stewart Smith, Lindsey Fiona Masson, Alastair McConnachie Cumming, Iain Broom, Neva Elizabeth Haites

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Associations between adult blood pressure and birth weight were investigated in 122 same-sex twin pairs aged 18-50 years and 86 singleton controls matched according to maternal age and parity, gender, gestational age, and current age who were recruited via an obstetric database in Aberdeen, Scotland, in 1999. Twins weighed on average 425 g less than controls at birth (p <0.001) but did not differ significantly in adult height or systolic or diastolic blood pressure from the controls. Among controls, the differences in systolic and diastolic blood pressure per kg of difference in birth weight, adjusted for gender, gestational age, current age, body mass index, smoking, physical activity level, and alcohol intake, were -4.3 (95% confidence interval (CI): -12.8, 4.3) and -6.1 (95% CI: -10.8, -1.5) mmHg/kg, respectively. In unpaired analysis among all twins, the equivalent values were -0.1 (95% CI: -4.0, 3.8) mmHg/kg for systolic pressure and -0.4 (95% CI: -2.9, 2.2) mmHg/kg for diastolic pressure, while in within-pair analysis the values were -0.9 (95% CI: -6.4, 4.6) mmHg/kg for systolic pressure and -0.2 (95% CI: -4.1, 3.7) mmHg/kg for diastolic pressure. The results suggest that in-utero growth restriction in twins is not a major determinant of their blood pressure as adults.
Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalAmerican Journal of Epidemiology
Volume158
Issue number2
DOIs
Publication statusPublished - 15 Jul 2003

Fingerprint

Birth Weight
Gestational Age
Blood Pressure
Confidence Intervals
Maternal Age
Scotland
Parity
Contraception
Obstetrics
Body Mass Index
Smoking
Alcohols
Databases
Growth

Keywords

  • Alcohol Drinking
  • Birth Weight
  • Blood Pressure
  • Body Mass Index
  • Case-Control Studies
  • Female
  • Gestational Age
  • Humans
  • Male
  • Physical Fitness
  • Questionnaires
  • Registries
  • Regression Analysis
  • Risk Factors
  • Scotland
  • Smoking
  • Statistics, Nonparametric
  • birth weight
  • blood pressure
  • twins

Cite this

Blood pressure in relation to birth weight in twins and singleton controls matched for gestational age. / McNeill, Geraldine; Tuya, Chuluuntulga; Campbell, Doris Margaret; Haggarty, Paul; Smith, William Cairns Stewart; Masson, Lindsey Fiona; Cumming, Alastair McConnachie; Broom, Iain; Haites, Neva Elizabeth.

In: American Journal of Epidemiology, Vol. 158, No. 2, 15.07.2003, p. 150-155.

Research output: Contribution to journalArticle

McNeill, Geraldine ; Tuya, Chuluuntulga ; Campbell, Doris Margaret ; Haggarty, Paul ; Smith, William Cairns Stewart ; Masson, Lindsey Fiona ; Cumming, Alastair McConnachie ; Broom, Iain ; Haites, Neva Elizabeth. / Blood pressure in relation to birth weight in twins and singleton controls matched for gestational age. In: American Journal of Epidemiology. 2003 ; Vol. 158, No. 2. pp. 150-155.
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abstract = "Associations between adult blood pressure and birth weight were investigated in 122 same-sex twin pairs aged 18-50 years and 86 singleton controls matched according to maternal age and parity, gender, gestational age, and current age who were recruited via an obstetric database in Aberdeen, Scotland, in 1999. Twins weighed on average 425 g less than controls at birth (p <0.001) but did not differ significantly in adult height or systolic or diastolic blood pressure from the controls. Among controls, the differences in systolic and diastolic blood pressure per kg of difference in birth weight, adjusted for gender, gestational age, current age, body mass index, smoking, physical activity level, and alcohol intake, were -4.3 (95{\%} confidence interval (CI): -12.8, 4.3) and -6.1 (95{\%} CI: -10.8, -1.5) mmHg/kg, respectively. In unpaired analysis among all twins, the equivalent values were -0.1 (95{\%} CI: -4.0, 3.8) mmHg/kg for systolic pressure and -0.4 (95{\%} CI: -2.9, 2.2) mmHg/kg for diastolic pressure, while in within-pair analysis the values were -0.9 (95{\%} CI: -6.4, 4.6) mmHg/kg for systolic pressure and -0.2 (95{\%} CI: -4.1, 3.7) mmHg/kg for diastolic pressure. The results suggest that in-utero growth restriction in twins is not a major determinant of their blood pressure as adults.",
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AU - McNeill, Geraldine

AU - Tuya, Chuluuntulga

AU - Campbell, Doris Margaret

AU - Haggarty, Paul

AU - Smith, William Cairns Stewart

AU - Masson, Lindsey Fiona

AU - Cumming, Alastair McConnachie

AU - Broom, Iain

AU - Haites, Neva Elizabeth

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N2 - Associations between adult blood pressure and birth weight were investigated in 122 same-sex twin pairs aged 18-50 years and 86 singleton controls matched according to maternal age and parity, gender, gestational age, and current age who were recruited via an obstetric database in Aberdeen, Scotland, in 1999. Twins weighed on average 425 g less than controls at birth (p <0.001) but did not differ significantly in adult height or systolic or diastolic blood pressure from the controls. Among controls, the differences in systolic and diastolic blood pressure per kg of difference in birth weight, adjusted for gender, gestational age, current age, body mass index, smoking, physical activity level, and alcohol intake, were -4.3 (95% confidence interval (CI): -12.8, 4.3) and -6.1 (95% CI: -10.8, -1.5) mmHg/kg, respectively. In unpaired analysis among all twins, the equivalent values were -0.1 (95% CI: -4.0, 3.8) mmHg/kg for systolic pressure and -0.4 (95% CI: -2.9, 2.2) mmHg/kg for diastolic pressure, while in within-pair analysis the values were -0.9 (95% CI: -6.4, 4.6) mmHg/kg for systolic pressure and -0.2 (95% CI: -4.1, 3.7) mmHg/kg for diastolic pressure. The results suggest that in-utero growth restriction in twins is not a major determinant of their blood pressure as adults.

AB - Associations between adult blood pressure and birth weight were investigated in 122 same-sex twin pairs aged 18-50 years and 86 singleton controls matched according to maternal age and parity, gender, gestational age, and current age who were recruited via an obstetric database in Aberdeen, Scotland, in 1999. Twins weighed on average 425 g less than controls at birth (p <0.001) but did not differ significantly in adult height or systolic or diastolic blood pressure from the controls. Among controls, the differences in systolic and diastolic blood pressure per kg of difference in birth weight, adjusted for gender, gestational age, current age, body mass index, smoking, physical activity level, and alcohol intake, were -4.3 (95% confidence interval (CI): -12.8, 4.3) and -6.1 (95% CI: -10.8, -1.5) mmHg/kg, respectively. In unpaired analysis among all twins, the equivalent values were -0.1 (95% CI: -4.0, 3.8) mmHg/kg for systolic pressure and -0.4 (95% CI: -2.9, 2.2) mmHg/kg for diastolic pressure, while in within-pair analysis the values were -0.9 (95% CI: -6.4, 4.6) mmHg/kg for systolic pressure and -0.2 (95% CI: -4.1, 3.7) mmHg/kg for diastolic pressure. The results suggest that in-utero growth restriction in twins is not a major determinant of their blood pressure as adults.

KW - Alcohol Drinking

KW - Birth Weight

KW - Blood Pressure

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KW - Case-Control Studies

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KW - Gestational Age

KW - Humans

KW - Male

KW - Physical Fitness

KW - Questionnaires

KW - Registries

KW - Regression Analysis

KW - Risk Factors

KW - Scotland

KW - Smoking

KW - Statistics, Nonparametric

KW - birth weight

KW - blood pressure

KW - twins

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DO - 10.1093/aje/kwg130

M3 - Article

VL - 158

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EP - 155

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

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ER -