Body mass index, occupational activity, and leisure-time physical activity

an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort

Kathryn R Martin, Diana Kuh, Tamara B Harris, Jack M Guralnik, David Coggon, Andrew K Wills

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Knee osteoarthritis (kOA) risk is increased by obesity and physical activities (PA) which mechanically stress the joint. We examined the associations of midlife kOA with body mass index (BMI) and activity exposure across adult life and their interaction.

METHODS: Data are from a UK birth cohort of 2597 participants with a clinical assessment for kOA at age 53. At ages 36, 43 and 53 BMI (kg/m2), self-reported leisure-time PA, and occupational activity (kneeling/squatting; lifting; climbing; sitting; assigned using a job-exposure matrix) were ascertained. Associations were explored using the multiplicative logistic model.

RESULTS: BMI was strongly and positively associated with kOA in men and women. Men and women in manual occupations also had greater odds of kOA; there was a weak suggestion that kOA risk was higher among men exposed to lifting or kneeling at work. For men, the only evidence of a multiplicative interaction between BMI and activities was for lifting (p = 0.01) at age 43; BMI conferred higher kOA risk among those most-likely to lift at work (OR per increase in BMI z-score: 3.55, 95% CI: 1.72-7.33). For women, the only evidence of an interaction was between BMI and leisure-time PA (p = 0.005) at age 43; BMI conferred higher kOA risk among those at higher PA levels (OR per increase in BMI z-score: 1.59, 95% CI: 1.26-2.00 in inactive; 1.70, 95% CI: 1.14-2.55 (less-active); and 4.44; 95% CI: 2.26-8.36 (most-active).

CONCLUSIONS: At the very least, our study suggests that more active individuals (at work and in leisure) may see a greater reduction in risk of kOA from avoiding a high BMI than those less active.

Original languageEnglish
Article number219
JournalBMC Musculoskeletal Disorders
Volume14
Early online date24 Jul 2013
DOIs
Publication statusPublished - 2013

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Knee Osteoarthritis
Leisure Activities
Body Mass Index
Parturition
Exercise
Risk Reduction Behavior
Occupations
Obesity
Joints
Logistic Models

Keywords

  • Adult
  • Body Mass Index
  • Comorbidity
  • Female
  • Great Britain
  • Humans
  • Leisure Activities
  • Life Style
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Motor Activity
  • Obesity
  • Occupational Diseases
  • Osteoarthritis, Knee
  • Quality of Life
  • Risk Factors
  • Occupational activity
  • Physical activity

Cite this

Body mass index, occupational activity, and leisure-time physical activity : an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort. / Martin, Kathryn R; Kuh, Diana; Harris, Tamara B; Guralnik, Jack M; Coggon, David; Wills, Andrew K.

In: BMC Musculoskeletal Disorders, Vol. 14, 219, 2013.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND: Knee osteoarthritis (kOA) risk is increased by obesity and physical activities (PA) which mechanically stress the joint. We examined the associations of midlife kOA with body mass index (BMI) and activity exposure across adult life and their interaction.METHODS: Data are from a UK birth cohort of 2597 participants with a clinical assessment for kOA at age 53. At ages 36, 43 and 53 BMI (kg/m2), self-reported leisure-time PA, and occupational activity (kneeling/squatting; lifting; climbing; sitting; assigned using a job-exposure matrix) were ascertained. Associations were explored using the multiplicative logistic model.RESULTS: BMI was strongly and positively associated with kOA in men and women. Men and women in manual occupations also had greater odds of kOA; there was a weak suggestion that kOA risk was higher among men exposed to lifting or kneeling at work. For men, the only evidence of a multiplicative interaction between BMI and activities was for lifting (p = 0.01) at age 43; BMI conferred higher kOA risk among those most-likely to lift at work (OR per increase in BMI z-score: 3.55, 95{\%} CI: 1.72-7.33). For women, the only evidence of an interaction was between BMI and leisure-time PA (p = 0.005) at age 43; BMI conferred higher kOA risk among those at higher PA levels (OR per increase in BMI z-score: 1.59, 95{\%} CI: 1.26-2.00 in inactive; 1.70, 95{\%} CI: 1.14-2.55 (less-active); and 4.44; 95{\%} CI: 2.26-8.36 (most-active).CONCLUSIONS: At the very least, our study suggests that more active individuals (at work and in leisure) may see a greater reduction in risk of kOA from avoiding a high BMI than those less active.",
keywords = "Adult, Body Mass Index, Comorbidity, Female, Great Britain, Humans, Leisure Activities, Life Style, Longitudinal Studies, Male, Middle Aged, Motor Activity, Obesity, Occupational Diseases, Osteoarthritis, Knee, Quality of Life, Risk Factors, Occupational activity, Physical activity",
author = "Martin, {Kathryn R} and Diana Kuh and Harris, {Tamara B} and Guralnik, {Jack M} and David Coggon and Wills, {Andrew K}",
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T2 - an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort

AU - Martin, Kathryn R

AU - Kuh, Diana

AU - Harris, Tamara B

AU - Guralnik, Jack M

AU - Coggon, David

AU - Wills, Andrew K

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Knee osteoarthritis (kOA) risk is increased by obesity and physical activities (PA) which mechanically stress the joint. We examined the associations of midlife kOA with body mass index (BMI) and activity exposure across adult life and their interaction.METHODS: Data are from a UK birth cohort of 2597 participants with a clinical assessment for kOA at age 53. At ages 36, 43 and 53 BMI (kg/m2), self-reported leisure-time PA, and occupational activity (kneeling/squatting; lifting; climbing; sitting; assigned using a job-exposure matrix) were ascertained. Associations were explored using the multiplicative logistic model.RESULTS: BMI was strongly and positively associated with kOA in men and women. Men and women in manual occupations also had greater odds of kOA; there was a weak suggestion that kOA risk was higher among men exposed to lifting or kneeling at work. For men, the only evidence of a multiplicative interaction between BMI and activities was for lifting (p = 0.01) at age 43; BMI conferred higher kOA risk among those most-likely to lift at work (OR per increase in BMI z-score: 3.55, 95% CI: 1.72-7.33). For women, the only evidence of an interaction was between BMI and leisure-time PA (p = 0.005) at age 43; BMI conferred higher kOA risk among those at higher PA levels (OR per increase in BMI z-score: 1.59, 95% CI: 1.26-2.00 in inactive; 1.70, 95% CI: 1.14-2.55 (less-active); and 4.44; 95% CI: 2.26-8.36 (most-active).CONCLUSIONS: At the very least, our study suggests that more active individuals (at work and in leisure) may see a greater reduction in risk of kOA from avoiding a high BMI than those less active.

AB - BACKGROUND: Knee osteoarthritis (kOA) risk is increased by obesity and physical activities (PA) which mechanically stress the joint. We examined the associations of midlife kOA with body mass index (BMI) and activity exposure across adult life and their interaction.METHODS: Data are from a UK birth cohort of 2597 participants with a clinical assessment for kOA at age 53. At ages 36, 43 and 53 BMI (kg/m2), self-reported leisure-time PA, and occupational activity (kneeling/squatting; lifting; climbing; sitting; assigned using a job-exposure matrix) were ascertained. Associations were explored using the multiplicative logistic model.RESULTS: BMI was strongly and positively associated with kOA in men and women. Men and women in manual occupations also had greater odds of kOA; there was a weak suggestion that kOA risk was higher among men exposed to lifting or kneeling at work. For men, the only evidence of a multiplicative interaction between BMI and activities was for lifting (p = 0.01) at age 43; BMI conferred higher kOA risk among those most-likely to lift at work (OR per increase in BMI z-score: 3.55, 95% CI: 1.72-7.33). For women, the only evidence of an interaction was between BMI and leisure-time PA (p = 0.005) at age 43; BMI conferred higher kOA risk among those at higher PA levels (OR per increase in BMI z-score: 1.59, 95% CI: 1.26-2.00 in inactive; 1.70, 95% CI: 1.14-2.55 (less-active); and 4.44; 95% CI: 2.26-8.36 (most-active).CONCLUSIONS: At the very least, our study suggests that more active individuals (at work and in leisure) may see a greater reduction in risk of kOA from avoiding a high BMI than those less active.

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KW - Body Mass Index

KW - Comorbidity

KW - Female

KW - Great Britain

KW - Humans

KW - Leisure Activities

KW - Life Style

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Motor Activity

KW - Obesity

KW - Occupational Diseases

KW - Osteoarthritis, Knee

KW - Quality of Life

KW - Risk Factors

KW - Occupational activity

KW - Physical activity

U2 - 10.1186/1471-2474-14-219

DO - 10.1186/1471-2474-14-219

M3 - Article

VL - 14

JO - BMC Musculoskeletal Disorders

JF - BMC Musculoskeletal Disorders

SN - 1471-2474

M1 - 219

ER -