Abstract

The bone graft system comprises a solid inorganic component, which is bone graft material, and a hydrogel. The hydrogel contains >2ppm of silicon ions, calculated as parts by weight of Si per million of the aqueous component of the hydrogel. Preferably, the solid inorganic component comprises hydroxyapatite or a silicon-containing hydroxyapatite, and may be a silicon- containing hydroxyapatite having a Ca/P ratio in the range 2.05 to 2.55 and a Ca/(P + Si) molar ratio less than 1.66. Bone healing is promoted by delivery of silicon ion release from the hydrogel and by the solid inorganic component stimulating cell behaviour.
Original languageEnglish
Patent numberWO2011/161409
IPCA61L27/52
Publication statusPublished - 15 Nov 2016

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