Abstract
Objectives: This article compares and combines methods for examining the external shape and the internal structure of the proximal femur with bone mineral density (BMD) to provide a classifier for hip fracture.
Materials and Methods: Fifty standard pelvic radiographs were available from age-matched fracture and control groups of postmenopausal women. Femoral shape was measured using an active shape model, the trabecular structure by means of a Fourier transform.
Results: Both the shape and various structure measures were independent of BMD (P = 0.16 and > 0.50, respectively). Calculating the area under the receiver operator characteristic (ROC) curve (A(z)), each of shape (A(z) = 0.81), the best structure measure (A(z) = 0.79-0.93), and BMD (A(z) = 0.79), could partially classify the fracture and control groups. However, the combination achieved almost perfect separation (A(z) = 0.99).
Conclusions: This pilot study shows how bone shape and structure can complement BMD measurements for investigations of fracture risk.
| Original language | English |
|---|---|
| Pages (from-to) | 591-597 |
| Number of pages | 6 |
| Journal | Investigative Radiology |
| Volume | 40 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sept 2005 |
Keywords
- shape
- density
- structure
- fracture
- osteoporosis
- finite-element-analysis
- power-spectral-analysis
- mineral density
- trabecular bone
- proximal femur
- femoral-neck
- mechanical-properties
- distal radius
- geometry
- radiographs