Objectives: This article compares and combines methods for examining the external shape and the internal structure of the proximal femur with bone mineral density (BMD) to provide a classifier for hip fracture.
Materials and Methods: Fifty standard pelvic radiographs were available from age-matched fracture and control groups of postmenopausal women. Femoral shape was measured using an active shape model, the trabecular structure by means of a Fourier transform.
Results: Both the shape and various structure measures were independent of BMD (P = 0.16 and > 0.50, respectively). Calculating the area under the receiver operator characteristic (ROC) curve (A(z)), each of shape (A(z) = 0.81), the best structure measure (A(z) = 0.79-0.93), and BMD (A(z) = 0.79), could partially classify the fracture and control groups. However, the combination achieved almost perfect separation (A(z) = 0.99).
Conclusions: This pilot study shows how bone shape and structure can complement BMD measurements for investigations of fracture risk.
|Number of pages||6|
|Publication status||Published - Sep 2005|
- mineral density
- trabecular bone
- proximal femur
- distal radius