Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

Hongsheng Zhang, Eunchai Kang, Yaqing Wang, Chaojuan Yang, Hui Yu, Qin Wang, Zheyu Chen, Chen Zhang, Kimberly M. Christian, Hongjun Song, Guo Li Ming*, Zhiheng Xu

*Corresponding author for this work

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Several genome- and proteome-wide studies have associated transcription and translation changes of CRMP2 (collapsing response mediator protein 2) with psychiatric disorders, yet little is known about its function in the developing or adult mammalian brain in vivo. Here we show that brain-specific Crmp2 knockout (cKO) mice display molecular, cellular, structural and behavioural deficits, many of which are reminiscent of neural features and symptoms associated with schizophrenia. cKO mice exhibit enlarged ventricles and impaired social behaviour, locomotor activity, and learning and memory. Loss of Crmp2 in the hippocampus leads to reduced long-term potentiation, abnormal NMDA receptor composition, aberrant dendrite development and defective synapse formation in CA1 neurons. Furthermore, knockdown of crmp2 specifically in newborn neurons results in stage-dependent defects in their development during adult hippocampal neurogenesis. Our findings reveal a critical role for CRMP2 in neuronal plasticity, neural function and behavioural modulation in mice.

Original languageEnglish
Article number11773
Number of pages12
JournalNature Communications
Volume7
DOIs
Publication statusPublished - 1 Jun 2016

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    Zhang, H., Kang, E., Wang, Y., Yang, C., Yu, H., Wang, Q., Chen, Z., Zhang, C., Christian, K. M., Song, H., Ming, G. L., & Xu, Z. (2016). Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nature Communications, 7, [11773]. https://doi.org/10.1038/ncomms11773