Breast Cancer Relapse, Post-Surgical Confusion, and Dementia in the Elderly

An Unexpected Connection but with the Same Proposed Solution

Michael W. Retsky, Patrice Forget (Corresponding Author)

Research output: Contribution to journalArticle

Abstract

A simple solution may exist for both the problem of sudden dementia and confusion after surgery in the elderly and the bimodal relapse pattern among breast cancer patients who were treated with a mastectomy. Systemic inflammation by a variety of mechanisms can induce tumor outgrowth from dormant states, such as single dormant cells and avascular micrometastases. This may also explain sudden confusion and dementia for the elderly after surgery. We propose that surgery-induced inflammation may be addressed by “protective anesthesia”. We suggest ketorolac for 4 days starting at the time of surgery to prevent early relapse in breast and probably other cancers; perhaps that or something similar could be used before surgery in elderly patients to prevent post-operative cognitive dysfunction.
Original languageEnglish
Article number101
JournalMedicina
Volume54
Issue number6
DOIs
Publication statusPublished - 3 Dec 2018

Fingerprint

Confusion
Dementia
Breast Neoplasms
Recurrence
Ketorolac
Inflammation
Neoplasm Micrometastasis
Mastectomy
Neoplasms
Breast
Anesthesia

Keywords

  • breast cancer relapse
  • confusion
  • dementia
  • inflammation

Cite this

@article{0f16b458a0f14557aa67effe6bcc4ae7,
title = "Breast Cancer Relapse, Post-Surgical Confusion, and Dementia in the Elderly: An Unexpected Connection but with the Same Proposed Solution",
abstract = "A simple solution may exist for both the problem of sudden dementia and confusion after surgery in the elderly and the bimodal relapse pattern among breast cancer patients who were treated with a mastectomy. Systemic inflammation by a variety of mechanisms can induce tumor outgrowth from dormant states, such as single dormant cells and avascular micrometastases. This may also explain sudden confusion and dementia for the elderly after surgery. We propose that surgery-induced inflammation may be addressed by “protective anesthesia”. We suggest ketorolac for 4 days starting at the time of surgery to prevent early relapse in breast and probably other cancers; perhaps that or something similar could be used before surgery in elderly patients to prevent post-operative cognitive dysfunction.",
keywords = "breast cancer relapse, confusion, dementia, inflammation",
author = "Retsky, {Michael W.} and Patrice Forget",
year = "2018",
month = "12",
day = "3",
doi = "10.3390/medicina54060101",
language = "English",
volume = "54",
journal = "Medicina",
issn = "1010-660X",
publisher = "MDPI AG",
number = "6",

}

TY - JOUR

T1 - Breast Cancer Relapse, Post-Surgical Confusion, and Dementia in the Elderly

T2 - An Unexpected Connection but with the Same Proposed Solution

AU - Retsky, Michael W.

AU - Forget, Patrice

PY - 2018/12/3

Y1 - 2018/12/3

N2 - A simple solution may exist for both the problem of sudden dementia and confusion after surgery in the elderly and the bimodal relapse pattern among breast cancer patients who were treated with a mastectomy. Systemic inflammation by a variety of mechanisms can induce tumor outgrowth from dormant states, such as single dormant cells and avascular micrometastases. This may also explain sudden confusion and dementia for the elderly after surgery. We propose that surgery-induced inflammation may be addressed by “protective anesthesia”. We suggest ketorolac for 4 days starting at the time of surgery to prevent early relapse in breast and probably other cancers; perhaps that or something similar could be used before surgery in elderly patients to prevent post-operative cognitive dysfunction.

AB - A simple solution may exist for both the problem of sudden dementia and confusion after surgery in the elderly and the bimodal relapse pattern among breast cancer patients who were treated with a mastectomy. Systemic inflammation by a variety of mechanisms can induce tumor outgrowth from dormant states, such as single dormant cells and avascular micrometastases. This may also explain sudden confusion and dementia for the elderly after surgery. We propose that surgery-induced inflammation may be addressed by “protective anesthesia”. We suggest ketorolac for 4 days starting at the time of surgery to prevent early relapse in breast and probably other cancers; perhaps that or something similar could be used before surgery in elderly patients to prevent post-operative cognitive dysfunction.

KW - breast cancer relapse

KW - confusion

KW - dementia

KW - inflammation

UR - http://www.mendeley.com/research/breast-cancer-relapse-postsurgical-confusion-dementia-elderly-unexpected-connection-same-proposed-so

U2 - 10.3390/medicina54060101

DO - 10.3390/medicina54060101

M3 - Article

VL - 54

JO - Medicina

JF - Medicina

SN - 1010-660X

IS - 6

M1 - 101

ER -