Breastfeeding and introduction of complementary foods during infancy in relation to the risk of asthma and atopic diseases up to 10 years

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Abstract

BACKGROUND: It has been hypothesized that changes in diet during early life may have contributed to the increase in childhood asthma and atopy. The long-term effect of the timing and content of infant feeding on the incidence of asthma and atopic diseases in children is unclear.

OBJECTIVE: To investigate the associations between duration of breastfeeding and the timing of introduction of complementary foods during the first 6 months and parental-reported asthma, wheeze and atopic eczema up to 10 years of age.

METHODS: Infant feeding practices (breastfeeding and introduction of complementary foods) of 1924 singleton children participating in the Study of Eczema and Asthma To Observe the influence of Nutrition (SEATON) birth cohort were prospectively collected up to 6 months with outcomes (wheeze, atopic eczema and asthma) being assessed at 1, 2, 5 and 10 years. Data were analysed using generalized estimating equations and discrete hazards models with adjustment for confounders.

RESULTS: By 6 months, 59% and 35% of mothers had stopped exclusive and total breastfeeding, respectively. Although formula feeding was adversely associated with wheeze in the past 12 months (adjusted OR for no formula feeding: 070, 95% CI 0.50-0.97), and the introduction of biscuits/bread after 5 months of age adversely associated with atopic eczema (adjusted OR 1.34, 95% CI 1.06-1.69), these results lost their statistical significance after adjustment for multiple testing. Stratification of the results by the presence of eczema by 6 months of age and family atopic history did not substantially differ from the results of the whole study population.

CONCLUSION AND CLINICAL RELEVANCE: Our results suggest that the nature of infant feeding during the first 6 months seems not to substantially influence the long-term risk of asthma and atopic diseases in children, nor in children at high risk of atopic disease because of a family history of atopic disease.

Original languageEnglish
Pages (from-to)1263-1273
Number of pages11
JournalClinical & experimental allergy
Volume43
Issue number11
Early online date24 Oct 2013
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Breast Feeding
Asthma
Food
Atopic Dermatitis
Eczema
Bread
Proportional Hazards Models
History
Mothers
Parturition
Diet
Incidence
Population

Keywords

  • Age Factors
  • Asthma
  • Breast Feeding
  • Child
  • Child, Preschool
  • Dermatitis, Atopic
  • Female
  • Follow-Up Studies
  • Humans
  • Hypersensitivity, Immediate
  • Infant
  • Infant Nutritional Physiological Phenomena
  • Male
  • Respiratory Sounds
  • Risk Factors
  • Children
  • Complementary Foods
  • Eczema
  • Formula Feeding
  • Wheeze

Cite this

@article{2d48a15da5ac4af09226ef8a46912b09,
title = "Breastfeeding and introduction of complementary foods during infancy in relation to the risk of asthma and atopic diseases up to 10 years",
abstract = "BACKGROUND: It has been hypothesized that changes in diet during early life may have contributed to the increase in childhood asthma and atopy. The long-term effect of the timing and content of infant feeding on the incidence of asthma and atopic diseases in children is unclear.OBJECTIVE: To investigate the associations between duration of breastfeeding and the timing of introduction of complementary foods during the first 6 months and parental-reported asthma, wheeze and atopic eczema up to 10 years of age.METHODS: Infant feeding practices (breastfeeding and introduction of complementary foods) of 1924 singleton children participating in the Study of Eczema and Asthma To Observe the influence of Nutrition (SEATON) birth cohort were prospectively collected up to 6 months with outcomes (wheeze, atopic eczema and asthma) being assessed at 1, 2, 5 and 10 years. Data were analysed using generalized estimating equations and discrete hazards models with adjustment for confounders.RESULTS: By 6 months, 59{\%} and 35{\%} of mothers had stopped exclusive and total breastfeeding, respectively. Although formula feeding was adversely associated with wheeze in the past 12 months (adjusted OR for no formula feeding: 070, 95{\%} CI 0.50-0.97), and the introduction of biscuits/bread after 5 months of age adversely associated with atopic eczema (adjusted OR 1.34, 95{\%} CI 1.06-1.69), these results lost their statistical significance after adjustment for multiple testing. Stratification of the results by the presence of eczema by 6 months of age and family atopic history did not substantially differ from the results of the whole study population.CONCLUSION AND CLINICAL RELEVANCE: Our results suggest that the nature of infant feeding during the first 6 months seems not to substantially influence the long-term risk of asthma and atopic diseases in children, nor in children at high risk of atopic disease because of a family history of atopic disease.",
keywords = "Age Factors, Asthma, Breast Feeding, Child, Child, Preschool, Dermatitis, Atopic, Female, Follow-Up Studies, Humans, Hypersensitivity, Immediate, Infant, Infant Nutritional Physiological Phenomena, Male, Respiratory Sounds, Risk Factors, Children, Complementary Foods, Eczema, Formula Feeding, Wheeze",
author = "Nwaru, {B I} and Craig, {L C A} and K Allan and N Prabhu and Turner, {S W} and G McNeill and M Erkkola and Anthony Seaton and Devereux, {Graham Stuart}",
note = "{\circledC} 2013 John Wiley & Sons Ltd. Funded by •Medical Research Counci •Asthma UK",
year = "2013",
month = "11",
doi = "10.1111/cea.12180",
language = "English",
volume = "43",
pages = "1263--1273",
journal = "Clinical & experimental allergy",
issn = "0954-7894",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Breastfeeding and introduction of complementary foods during infancy in relation to the risk of asthma and atopic diseases up to 10 years

AU - Nwaru, B I

AU - Craig, L C A

AU - Allan, K

AU - Prabhu, N

AU - Turner, S W

AU - McNeill, G

AU - Erkkola, M

AU - Seaton, Anthony

AU - Devereux, Graham Stuart

N1 - © 2013 John Wiley & Sons Ltd. Funded by •Medical Research Counci •Asthma UK

PY - 2013/11

Y1 - 2013/11

N2 - BACKGROUND: It has been hypothesized that changes in diet during early life may have contributed to the increase in childhood asthma and atopy. The long-term effect of the timing and content of infant feeding on the incidence of asthma and atopic diseases in children is unclear.OBJECTIVE: To investigate the associations between duration of breastfeeding and the timing of introduction of complementary foods during the first 6 months and parental-reported asthma, wheeze and atopic eczema up to 10 years of age.METHODS: Infant feeding practices (breastfeeding and introduction of complementary foods) of 1924 singleton children participating in the Study of Eczema and Asthma To Observe the influence of Nutrition (SEATON) birth cohort were prospectively collected up to 6 months with outcomes (wheeze, atopic eczema and asthma) being assessed at 1, 2, 5 and 10 years. Data were analysed using generalized estimating equations and discrete hazards models with adjustment for confounders.RESULTS: By 6 months, 59% and 35% of mothers had stopped exclusive and total breastfeeding, respectively. Although formula feeding was adversely associated with wheeze in the past 12 months (adjusted OR for no formula feeding: 070, 95% CI 0.50-0.97), and the introduction of biscuits/bread after 5 months of age adversely associated with atopic eczema (adjusted OR 1.34, 95% CI 1.06-1.69), these results lost their statistical significance after adjustment for multiple testing. Stratification of the results by the presence of eczema by 6 months of age and family atopic history did not substantially differ from the results of the whole study population.CONCLUSION AND CLINICAL RELEVANCE: Our results suggest that the nature of infant feeding during the first 6 months seems not to substantially influence the long-term risk of asthma and atopic diseases in children, nor in children at high risk of atopic disease because of a family history of atopic disease.

AB - BACKGROUND: It has been hypothesized that changes in diet during early life may have contributed to the increase in childhood asthma and atopy. The long-term effect of the timing and content of infant feeding on the incidence of asthma and atopic diseases in children is unclear.OBJECTIVE: To investigate the associations between duration of breastfeeding and the timing of introduction of complementary foods during the first 6 months and parental-reported asthma, wheeze and atopic eczema up to 10 years of age.METHODS: Infant feeding practices (breastfeeding and introduction of complementary foods) of 1924 singleton children participating in the Study of Eczema and Asthma To Observe the influence of Nutrition (SEATON) birth cohort were prospectively collected up to 6 months with outcomes (wheeze, atopic eczema and asthma) being assessed at 1, 2, 5 and 10 years. Data were analysed using generalized estimating equations and discrete hazards models with adjustment for confounders.RESULTS: By 6 months, 59% and 35% of mothers had stopped exclusive and total breastfeeding, respectively. Although formula feeding was adversely associated with wheeze in the past 12 months (adjusted OR for no formula feeding: 070, 95% CI 0.50-0.97), and the introduction of biscuits/bread after 5 months of age adversely associated with atopic eczema (adjusted OR 1.34, 95% CI 1.06-1.69), these results lost their statistical significance after adjustment for multiple testing. Stratification of the results by the presence of eczema by 6 months of age and family atopic history did not substantially differ from the results of the whole study population.CONCLUSION AND CLINICAL RELEVANCE: Our results suggest that the nature of infant feeding during the first 6 months seems not to substantially influence the long-term risk of asthma and atopic diseases in children, nor in children at high risk of atopic disease because of a family history of atopic disease.

KW - Age Factors

KW - Asthma

KW - Breast Feeding

KW - Child

KW - Child, Preschool

KW - Dermatitis, Atopic

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Hypersensitivity, Immediate

KW - Infant

KW - Infant Nutritional Physiological Phenomena

KW - Male

KW - Respiratory Sounds

KW - Risk Factors

KW - Children

KW - Complementary Foods

KW - Eczema

KW - Formula Feeding

KW - Wheeze

U2 - 10.1111/cea.12180

DO - 10.1111/cea.12180

M3 - Article

VL - 43

SP - 1263

EP - 1273

JO - Clinical & experimental allergy

JF - Clinical & experimental allergy

SN - 0954-7894

IS - 11

ER -