Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

J. Nithianantharajah; A. G. McKechanie; T. J. Stewart; M. Johnstone; D. H. Blackwood; D. St Clair; S. G.N. Grant; T. J. Bussey; L. M. Saksida

doi:10.1038/srep14613

Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

J. Nithianantharajah^* (Corresponding Author), A. G. McKechanie, T. J. Stewart, M. Johnstone, D. H. Blackwood, D. St Clair, S. G.N. Grant, T. J. Bussey, L. M. Saksida

^*Corresponding author for this work

Institute of Medical Sciences

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Abstract

Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.

Original language	English
Article number	14613
Number of pages	5
Journal	Scientific Reports
Volume	5
Early online date	1 Oct 2015
DOIs	https://doi.org/10.1038/srep14613
Publication status	Published - 1 Oct 2015

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Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., ... Saksida, L. M. (2015). Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. Scientific Reports, 5, [14613]. https://doi.org/10.1038/srep14613

Bridging the translational divide : Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. / Nithianantharajah, J. (Corresponding Author); McKechanie, A. G.; Stewart, T. J.; Johnstone, M.; Blackwood, D. H.; St Clair, D.; Grant, S. G.N.; Bussey, T. J.; Saksida, L. M.

In: Scientific Reports, Vol. 5, 14613, 01.10.2015.

Research output: Contribution to journal › Article

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note = "Acknowledgements J.N. and S.G.N.G. supported by The Wellcome Trust, Genes to Cognition Program, The Medical Research Council (MRC) and EU programs (Project GENCODYS No. 241995, Project EUROSPIN No. 242498 and Project SYNSYS No. 242167). Figure illustration contribution by D.J. Maizels.",

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Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease relevant homologous gene
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