Abstract
Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.
| Original language | English |
|---|---|
| Article number | 14613 |
| Number of pages | 5 |
| Journal | Scientific Reports |
| Volume | 5 |
| Early online date | 1 Oct 2015 |
| DOIs | |
| Publication status | Published - 1 Oct 2015 |
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Bridging the translational divide : Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. / Nithianantharajah, J. (Corresponding Author); McKechanie, A. G.; Stewart, T. J.; Johnstone, M.; Blackwood, D. H.; St Clair, D.; Grant, S. G.N.; Bussey, T. J.; Saksida, L. M.
In: Scientific Reports, Vol. 5, 14613, 01.10.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bridging the translational divide
T2 - Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
AU - Nithianantharajah, J.
AU - McKechanie, A. G.
AU - Stewart, T. J.
AU - Johnstone, M.
AU - Blackwood, D. H.
AU - St Clair, D.
AU - Grant, S. G.N.
AU - Bussey, T. J.
AU - Saksida, L. M.
N1 - Acknowledgements J.N. and S.G.N.G. supported by The Wellcome Trust, Genes to Cognition Program, The Medical Research Council (MRC) and EU programs (Project GENCODYS No. 241995, Project EUROSPIN No. 242498 and Project SYNSYS No. 242167). Figure illustration contribution by D.J. Maizels.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.
AB - Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.
UR - http://www.scopus.com/inward/record.url?scp=84943196360&partnerID=8YFLogxK
U2 - 10.1038/srep14613
DO - 10.1038/srep14613
M3 - Article
C2 - 26423861
AN - SCOPUS:84943196360
VL - 5
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 14613
ER -