Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

J. Nithianantharajah (Corresponding Author), A. G. McKechanie, T. J. Stewart, M. Johnstone, D. H. Blackwood, D. St Clair, S. G.N. Grant, T. J. Bussey, L. M. Saksida

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Abstract

Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.

Original languageEnglish
Article number14613
Number of pages5
JournalScientific Reports
Volume5
Early online date1 Oct 2015
DOIs
Publication statusPublished - 1 Oct 2015

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Mutation
Inborn Genetic Diseases
Brain Diseases
Genes
Therapeutics
Cognitive Dysfunction

ASJC Scopus subject areas

  • General

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Bridging the translational divide : Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. / Nithianantharajah, J. (Corresponding Author); McKechanie, A. G.; Stewart, T. J.; Johnstone, M.; Blackwood, D. H.; St Clair, D.; Grant, S. G.N.; Bussey, T. J.; Saksida, L. M.

In: Scientific Reports, Vol. 5, 14613, 01.10.2015.

Research output: Contribution to journalArticle

Nithianantharajah, J, McKechanie, AG, Stewart, TJ, Johnstone, M, Blackwood, DH, St Clair, D, Grant, SGN, Bussey, TJ & Saksida, LM 2015, 'Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene' Scientific Reports, vol. 5, 14613. https://doi.org/10.1038/srep14613
Nithianantharajah, J. ; McKechanie, A. G. ; Stewart, T. J. ; Johnstone, M. ; Blackwood, D. H. ; St Clair, D. ; Grant, S. G.N. ; Bussey, T. J. ; Saksida, L. M. / Bridging the translational divide : Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. In: Scientific Reports. 2015 ; Vol. 5.
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