Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

J. Nithianantharajah; A. G. McKechanie; T. J. Stewart; M. Johnstone; D. H. Blackwood; D. St Clair; S. G.N. Grant; T. J. Bussey; L. M. Saksida

doi:10.1038/srep14613

Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

J. Nithianantharajah^* (Corresponding Author), A. G. McKechanie, T. J. Stewart, M. Johnstone, D. H. Blackwood, D. St Clair, S. G.N. Grant, T. J. Bussey, L. M. Saksida

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

12 Downloads (Pure)

Abstract

Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.

Original language	English
Article number	14613
Number of pages	5
Journal	Scientific Reports
Volume	5
Early online date	1 Oct 2015
DOIs	https://doi.org/10.1038/srep14613
Publication status	Published - 1 Oct 2015

Access to Document

10.1038/srep14613Licence: CC BY

Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease relevant homologous gene
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Final published version, 370 KBLicence: CC BY

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene'. Together they form a unique fingerprint.

Cite this

Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., Grant, S. G. N., Bussey, T. J., & Saksida, L. M. (2015). Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. Scientific Reports, 5, [14613]. https://doi.org/10.1038/srep14613

Bridging the translational divide : Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. / Nithianantharajah, J. (Corresponding Author); McKechanie, A. G.; Stewart, T. J.; Johnstone, M.; Blackwood, D. H.; St Clair, D.; Grant, S. G.N.; Bussey, T. J.; Saksida, L. M.

In: Scientific Reports, Vol. 5, 14613, 01.10.2015.

Research output: Contribution to journal › Article › peer-review

@article{fc0a840af8374e5c850472e582a19b36,

title = "Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene",

abstract = "Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.",

author = "J. Nithianantharajah and McKechanie, {A. G.} and Stewart, {T. J.} and M. Johnstone and Blackwood, {D. H.} and {St Clair}, D. and Grant, {S. G.N.} and Bussey, {T. J.} and Saksida, {L. M.}",

note = "Acknowledgements J.N. and S.G.N.G. supported by The Wellcome Trust, Genes to Cognition Program, The Medical Research Council (MRC) and EU programs (Project GENCODYS No. 241995, Project EUROSPIN No. 242498 and Project SYNSYS No. 242167). Figure illustration contribution by D.J. Maizels.",

year = "2015",

month = oct,

day = "1",

doi = "10.1038/srep14613",

language = "English",

volume = "5",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Bridging the translational divide

T2 - Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

AU - Nithianantharajah, J.

AU - McKechanie, A. G.

AU - Stewart, T. J.

AU - Johnstone, M.

AU - Blackwood, D. H.

AU - St Clair, D.

AU - Grant, S. G.N.

AU - Bussey, T. J.

AU - Saksida, L. M.

N1 - Acknowledgements J.N. and S.G.N.G. supported by The Wellcome Trust, Genes to Cognition Program, The Medical Research Council (MRC) and EU programs (Project GENCODYS No. 241995, Project EUROSPIN No. 242498 and Project SYNSYS No. 242167). Figure illustration contribution by D.J. Maizels.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.

AB - Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.

UR - http://www.scopus.com/inward/record.url?scp=84943196360&partnerID=8YFLogxK

U2 - 10.1038/srep14613

DO - 10.1038/srep14613

M3 - Article

C2 - 26423861

AN - SCOPUS:84943196360

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 14613

ER -