Bronchial hyperresponsiveness and adult onset wheeze

the influence of atopy

C Bodner, D Godden, S Ross, J Little, J G Douglas, J Legge, A Seaton, J Friend

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The commonly held belief that adult onset wheezing illness is primarily nonatopic in nature suggests that the role of atopy in the pathophysiology of bronchial hyperresponsiveness (BHR) in adult onset wheeze may be minimal.

This study examined risk factors for BHR (BHR: provocative dose causing a 20% fall in forced expiratory volume in one second PD20 less than or equal to 16.38 mu mol methacholine) among 82 subjects with adult onset wheeze and among 191 subjects who had never wheezed. Subjects were identified from a cohort of subjects aged 39-45 yrs who were known to have had no childhood wheeze and who were involved in a 30 yr follow-up survey Risk factors for BHR were examined among all subjects with BHR and among subjects with BHR stratified according to whether or not they had ever wheezed.

The prevalence of BHR was 40% (33/82) among the subjects with adult onset wheeze and 11% (21/191) among the subjects who had never wheezed, Lower baseline lung function (odds ratio (OR)= 0.94; 95% confidence interval (CT)= 0.92-0.97 per unit forced expiratory volume (FEV1)% predicted) and atopy (OR = 7.23; Cl = 2.53-20.64 for all three measures of atopic compared to nonatopic) were associated with BHR, while smoking and family history showed no statistically significant relation to BHR This pattern was also apparent in analyses stratified by symptom status. A family history of atopy increased the risk that BHR was accompanied by wheezing symptoms (OR = 4.75; CI = 1.53-14.72 for more than one affected relative compared to no affected relatives).

These findings suggest that atopy is associated with bronchial hyperresponsiveness in adults known to have had no childhood wheeze. A familial factor reflecting genetic influences and/or shared environmental factors may influence whether bronchial hyperresponsiveness is associated with symptoms.

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalEuropean Respiratory Journal
Volume14
Publication statusPublished - 1999

Keywords

  • adult onset
  • atopy
  • bronchial hyperresponsiveness
  • epidemiology
  • risk factors
  • airway hyperresponsiveness
  • respiratory symptoms
  • pulmonary-function
  • older men
  • responsiveness
  • asthma
  • methacholine
  • prevalence
  • allergens
  • childhood

Cite this

Bodner, C., Godden, D., Ross, S., Little, J., Douglas, J. G., Legge, J., ... Friend, J. (1999). Bronchial hyperresponsiveness and adult onset wheeze: the influence of atopy. European Respiratory Journal, 14, 335-338.

Bronchial hyperresponsiveness and adult onset wheeze : the influence of atopy. / Bodner, C ; Godden, D ; Ross, S ; Little, J ; Douglas, J G ; Legge, J ; Seaton, A ; Friend, J .

In: European Respiratory Journal, Vol. 14, 1999, p. 335-338.

Research output: Contribution to journalArticle

Bodner, C, Godden, D, Ross, S, Little, J, Douglas, JG, Legge, J, Seaton, A & Friend, J 1999, 'Bronchial hyperresponsiveness and adult onset wheeze: the influence of atopy', European Respiratory Journal, vol. 14, pp. 335-338.
Bodner, C ; Godden, D ; Ross, S ; Little, J ; Douglas, J G ; Legge, J ; Seaton, A ; Friend, J . / Bronchial hyperresponsiveness and adult onset wheeze : the influence of atopy. In: European Respiratory Journal. 1999 ; Vol. 14. pp. 335-338.
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AU - Ross, S

AU - Little, J

AU - Douglas, J G

AU - Legge, J

AU - Seaton, A

AU - Friend, J

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AB - The commonly held belief that adult onset wheezing illness is primarily nonatopic in nature suggests that the role of atopy in the pathophysiology of bronchial hyperresponsiveness (BHR) in adult onset wheeze may be minimal.This study examined risk factors for BHR (BHR: provocative dose causing a 20% fall in forced expiratory volume in one second PD20 less than or equal to 16.38 mu mol methacholine) among 82 subjects with adult onset wheeze and among 191 subjects who had never wheezed. Subjects were identified from a cohort of subjects aged 39-45 yrs who were known to have had no childhood wheeze and who were involved in a 30 yr follow-up survey Risk factors for BHR were examined among all subjects with BHR and among subjects with BHR stratified according to whether or not they had ever wheezed.The prevalence of BHR was 40% (33/82) among the subjects with adult onset wheeze and 11% (21/191) among the subjects who had never wheezed, Lower baseline lung function (odds ratio (OR)= 0.94; 95% confidence interval (CT)= 0.92-0.97 per unit forced expiratory volume (FEV1)% predicted) and atopy (OR = 7.23; Cl = 2.53-20.64 for all three measures of atopic compared to nonatopic) were associated with BHR, while smoking and family history showed no statistically significant relation to BHR This pattern was also apparent in analyses stratified by symptom status. A family history of atopy increased the risk that BHR was accompanied by wheezing symptoms (OR = 4.75; CI = 1.53-14.72 for more than one affected relative compared to no affected relatives).These findings suggest that atopy is associated with bronchial hyperresponsiveness in adults known to have had no childhood wheeze. A familial factor reflecting genetic influences and/or shared environmental factors may influence whether bronchial hyperresponsiveness is associated with symptoms.

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KW - atopy

KW - bronchial hyperresponsiveness

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KW - risk factors

KW - airway hyperresponsiveness

KW - respiratory symptoms

KW - pulmonary-function

KW - older men

KW - responsiveness

KW - asthma

KW - methacholine

KW - prevalence

KW - allergens

KW - childhood

M3 - Article

VL - 14

SP - 335

EP - 338

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

ER -