@article{52b56ff95e11499384f02695ed3032d5,
title = "Brown adipose tissue transplantation reverses obesity in Ob/Ob mice",
abstract = "Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted BAT from C57/BL6 mice into the dorsal subcutaneous region of age- and sex-matched leptin deficient Ob/Ob mice. Interestingly, BAT transplantation led to a significant reduction of body weight gain with increased oxygen consumption and decreased total body fat mass, resulting in improvement of insulin resistance and liver steatosis. In addition, BAT transplantation increased the level of circulating adiponectin, whereas it reduced the levels of circulating free T3 and T4, which regulate thyroid hormone sensitivity in peripheral tissues. BAT transplantation also increased 3-adrenergic receptor and fatty acidoxidation relatedgene expressionin subcutaneous and epididymal (EP) white adipose tissue. Accordingly, BAT transplantation increased whole-body thermogenesis. Taken together our results demonstrate that BAT transplantation may reduce obesity and its related diseases by activating endogenous BAT.",
keywords = "Brown Adipose Tissue, BAT, Transplantation, Obesity, Mice, White adipose tissue, WAT",
author = "Xiaomeng Liu and Siping Wang and Yilin You and Minghui Meng and Zongji Zheng and Meng Dong and Jun Lin and Qianwei Zhao and Chuanhai Zhang and Xiaoxue Yuan and Tao Hu and Lieqin Liu and Yuanyuan Huang and Lei Zhang and Dehua Wang and Jicheng Zhan and Lee, {Hyuek Jong} and Speakman, {John R} and Wanzhu Jin",
note = "Acknowledgments Author contributions include the following: W.J. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. W.Z.J., X.M.L., S.P.W., H.J.L., J.S.R., and Y.L.Y. wrote the manuscript; MHM performed the histology, imaging studies and Western blot; Z.J.Z. and X.M.L. performed the energy metabolism assays and the gene expression analysis; M.D., J.L., Q.W.Z., C.H.Z., X.X.Y., T.H., and L.Q.L. performed the animal surgery and the GTT and ITT studies; and L.Z., D.H.W., and J.C.Z. contributed to the discussion and editing of the manuscript. This work was supported by the Strategic Priority Research Program (XDB13030000), the Key Research Program (KJZD-EW-L01-03) of the Chinese Academy of Sciences, a grant from the Ministry of Science and Technology of China (2012CBA01301, 2012CB944701), and the National Natural Science Foundation of China (81370951, 31171131) to W.J. ",
year = "2015",
month = jul,
doi = "10.1210/en.2014-1598",
language = "English",
volume = "156",
pages = "2461--2469",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "7",
}
