Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310

Kwaku Kyeremeh (Corresponding Author), Kojo Acquah, Anil Sazak, Wael E Houssen, Jioji Tabudravu, Hai Deng, Marcel Jaspars (Corresponding Author)

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Abstract

A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin (2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of
5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes.
Original languageEnglish
Article number12
Pages (from-to)999-1012
Number of pages13
JournalMarine Drugs
Volume12
Issue number2
DOIs
Publication statusPublished - 14 Feb 2014

Keywords

  • micromonospora
  • macrolactam
  • tautomer acid
  • mangroves

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