C-type lectin-like receptors of the dectin-1 cluster

ligands and signaling pathways

Anthony Plato, Janet A Willment, Gordon D Brown

Research output: Contribution to journalArticle

78 Citations (Scopus)
7 Downloads (Pure)

Abstract

Innate immunity is constructed around genetically encoded receptors that survey the intracellular and extracellular environments for signs of invading microorganisms. These receptors recognise the invader and through complex intracellular networks of molecular signaling, they destroy the threat whilst instructing effective adaptive immune responses. Many of these receptors, like the Toll-like receptors in particular, are well-known for their ability to mediate downstream responses upon recognition of exogenous or endogenous ligands; however, the emerging family known as the C-type lectin-like receptors contains many members that have a huge impact on immune and homeostatic regulation. Of particular interest here are the C-type lectin-like receptors that make up the Dectin-1 cluster and their intracellular signaling motifs that mediate their functions. In this review, we aim to draw together current knowledge of ligands, motifs and signaling pathways, present downstream of Dectin-1 cluster receptors, and discuss how these dictate their role within biological systems.
Original languageEnglish
Pages (from-to)134-156
Number of pages23
JournalInternational Reviews of Immunology
Volume32
Issue number2
DOIs
Publication statusPublished - Apr 2013

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C-Type Lectins
Ligands
Toll-Like Receptors
Adaptive Immunity
Innate Immunity
dectin 1
Surveys and Questionnaires

Keywords

  • C-type lectin
  • ITAM-like
  • ITIM
  • tri-acidic
  • Syk

Cite this

C-type lectin-like receptors of the dectin-1 cluster : ligands and signaling pathways. / Plato, Anthony; Willment, Janet A; Brown, Gordon D.

In: International Reviews of Immunology, Vol. 32, No. 2, 04.2013, p. 134-156.

Research output: Contribution to journalArticle

Plato, Anthony ; Willment, Janet A ; Brown, Gordon D. / C-type lectin-like receptors of the dectin-1 cluster : ligands and signaling pathways. In: International Reviews of Immunology. 2013 ; Vol. 32, No. 2. pp. 134-156.
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