C-type lectin receptors in antifungal immunity

Janet Anne Willment, Gordon Douglas Brown

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

Fungal infections represent a significant health burden, especially in immunocompromised individuals, yet many of the underlying immunological mechanisms involved in the recognition and control of these pathogens are unclear. The identification of the Toll-like receptors (TLRs) has shed new insights on innate microbial recognition and the initiation of immune responses; however, recent evidence indicates that the 'non-TLR' receptors also have a significant role in these processes, particularly in antifungal immunity. Of interest are members of the C-type lectin-receptor family, including the mannose receptor, dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3)-grabbing non-integrin (DC-SIGN), Dectin-1, Dectin-2 and the collectins. Here, we review the roles of each of these receptors, describing how they contribute to fungal recognition, uptake and killing and also participate in the induction and/or modulation of the host immune response.
Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalTrends in Microbiology
Volume16
Issue number1
Early online date21 Dec 2007
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Collectins
C-Type Lectins
Mycoses
Toll-Like Receptors
Cell Adhesion Molecules
Dendritic Cells
Immunity
Health
dectin 1
DC-specific ICAM-3 grabbing nonintegrin
mannose receptor
mouse dectin-2

Keywords

  • Animals
  • Fungi
  • Humans
  • Mycoses
  • Receptors, Mitogen

Cite this

C-type lectin receptors in antifungal immunity. / Willment, Janet Anne; Brown, Gordon Douglas.

In: Trends in Microbiology, Vol. 16, No. 1, 01.2008, p. 27-32.

Research output: Contribution to journalArticle

Willment, Janet Anne ; Brown, Gordon Douglas. / C-type lectin receptors in antifungal immunity. In: Trends in Microbiology. 2008 ; Vol. 16, No. 1. pp. 27-32.
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