C-type lectin receptors in antifungal immunity

Janet Anne Willment, Gordon Douglas Brown

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Fungal infections represent a significant health burden, especially in immunocompromised individuals, yet many of the underlying immunological mechanisms involved in the recognition and control of these pathogens are unclear. The identification of the Toll-like receptors (TLRs) has shed new insights on innate microbial recognition and the initiation of immune responses; however, recent evidence indicates that the 'non-TLR' receptors also have a significant role in these processes, particularly in antifungal immunity. Of interest are members of the C-type lectin-receptor family, including the mannose receptor, dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3)-grabbing non-integrin (DC-SIGN), Dectin-1, Dectin-2 and the collectins. Here, we review the roles of each of these receptors, describing how they contribute to fungal recognition, uptake and killing and also participate in the induction and/or modulation of the host immune response.
Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalTrends in Microbiology
Volume16
Issue number1
Early online date21 Dec 2007
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Animals
  • Fungi
  • Humans
  • Mycoses
  • Receptors, Mitogen

Fingerprint Dive into the research topics of 'C-type lectin receptors in antifungal immunity'. Together they form a unique fingerprint.

  • Cite this