Abstract
C-type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin-1 cluster, comprising of seven receptors including MICL, CLEC-2, CLEC-12B, CLEC-9A, MelLec, Dectin-1 and LOX-1. Reflecting the larger CLR family, the Dectin-1 cluster of receptors has a broad range of ligands and functions, but importantly, are involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis and other autoimmune diseases. In this mini-review, we discuss the latest advancements in elucidating the function(s) of each of the Dectin-1 cluster CLRs, focussing on their physiological roles and involvement in disease
Original language | English |
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Pages (from-to) | 2127-2133 |
Number of pages | 7 |
Journal | European Journal of Immunology |
Volume | 49 |
Issue number | 12 |
Early online date | 13 Nov 2019 |
DOIs | |
Publication status | Published - Dec 2019 |
Bibliographical note
Acknowledgements: We apologise to our many colleagues whose valuable work we could not cite due to space constraints. Funding was provided by the Wellcome Trust (102705, 097377), the Medical Research Council Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). KT received a research fellowship from Jikei University School of Medicine.Keywords
- C-type lectin
- Dectin-1
- autoimmunity
- immunity