C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease

Kazuya Tone, Mark H.T. Stappers, Janet A. Willment (Corresponding Author), Gordon D. Brown (Corresponding Author)

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Abstract

C-type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin-1 cluster, comprising of seven receptors including MICL, CLEC-2, CLEC-12B, CLEC-9A, MelLec, Dectin-1 and LOX-1. Reflecting the larger CLR family, the Dectin-1 cluster of receptors has a broad range of ligands and functions, but importantly, are involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis and other autoimmune diseases. In this mini-review, we discuss the latest advancements in elucidating the function(s) of each of the Dectin-1 cluster CLRs, focussing on their physiological roles and involvement in disease
Original languageEnglish
Pages (from-to)2127-2133
Number of pages7
JournalEuropean Journal of Immunology
Volume49
Issue number12
Early online date13 Nov 2019
DOIs
Publication statusPublished - Dec 2019

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Keywords

  • C-type lectin
  • Dectin-1
  • autoimmunity
  • immunity

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