C-type lectin receptors orchestrate antifungal immunity

Sarah E. Hardison, Gordon D. Brown*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

325 Citations (Scopus)


Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.
Original languageEnglish
Pages (from-to)817-822
Number of pages6
JournalNature Immunology
Issue number9
Early online date21 Aug 2012
Publication statusPublished - 1 Sep 2012


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