C-type lectin receptors orchestrate antifungal immunity

Sarah E. Hardison, Gordon D. Brown*

*Corresponding author for this work

Research output: Contribution to journalArticle

226 Citations (Scopus)

Abstract

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.
Original languageEnglish
Pages (from-to)817-822
Number of pages6
JournalNature Immunology
Volume13
Issue number9
Early online date21 Aug 2012
DOIs
Publication statusPublished - 1 Sep 2012

Fingerprint

C-Type Lectins
Pattern Recognition Receptors
Immunity
Mycoses
Adaptive Immunity
Innate Immunity
Vaccines

Cite this

C-type lectin receptors orchestrate antifungal immunity. / Hardison, Sarah E.; Brown, Gordon D.

In: Nature Immunology, Vol. 13, No. 9, 01.09.2012, p. 817-822.

Research output: Contribution to journalArticle

Hardison, Sarah E. ; Brown, Gordon D. / C-type lectin receptors orchestrate antifungal immunity. In: Nature Immunology. 2012 ; Vol. 13, No. 9. pp. 817-822.
@article{bc8747c6b20c4f968ede499b5716c3d8,
title = "C-type lectin receptors orchestrate antifungal immunity",
abstract = "Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.",
author = "Hardison, {Sarah E.} and Brown, {Gordon D.}",
year = "2012",
month = "9",
day = "1",
doi = "10.1038/ni.2369",
language = "English",
volume = "13",
pages = "817--822",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - C-type lectin receptors orchestrate antifungal immunity

AU - Hardison, Sarah E.

AU - Brown, Gordon D.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.

AB - Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.

UR - http://www.scopus.com/inward/record.url?scp=84865411904&partnerID=8YFLogxK

U2 - 10.1038/ni.2369

DO - 10.1038/ni.2369

M3 - Article

VL - 13

SP - 817

EP - 822

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 9

ER -