C-type lectins and phagocytosis

Ann Kerrigan, Gordon D Brown

Research output: Contribution to journalArticlepeer-review

180 Citations (Scopus)
3 Downloads (Pure)

Abstract

To recognise and respond to pathogens, germ-line encoded pattern recognition receptors (PRRs) bind to conserved microbial structures and activate host defence systems, including microbial uptake by phagocytosis. Phagocytosis is a complex process that is instrumental in the control of extracellular pathogens, and this activity is mediated by several PRRs, including a number of C-type lectins. While some of these receptors have clearly been shown to mediate or regulate the uptake of pathogens, others are more contentious and are less well understood in terms of their phagocytic potential. Furthermore, very little is known about the underlying phagocytic mechanisms. Here, we review the phagocytic roles of the mannose receptor, Dectin-1, dendritic cell-specific ICAM grabbing non-integrin (DC-SIGN), DCL-1, mannose binding lectin and surfactant proteins A and D.
Original languageEnglish
Pages (from-to)562-575
Number of pages14
JournalImmunobiology
Volume214
Issue number7
Early online date3 Mar 2009
DOIs
Publication statusPublished - Jul 2009

Keywords

  • collectin
  • DC-SIGN
  • Dectin-1
  • mannose receptor
  • pattern recognition receptor

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