C-type lectins in immunity: recent developments

Ivy M Dambuza, Gordon D Brown

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Abstract

C-type lectin receptors (CLRs) comprise a large superfamily of proteins, which recognise a diverse range of ligands, and are defined by the presence of at least one C-type lectin-like domain (CTLD). Of particular interest are the single extracellular CTLD-containing receptors of the ‘Dectin-1’ and ‘Dectin-2’ clusters, which associate with signalling adaptors or possess integral intracellular signalling domains. These CLRs have traditionally been associated with the recognition of fungi, but recent discoveries have revealed diverse and unexpected functions. In this review, we describe their newly identified roles in anti-microbial host defence, homeostasis, autoimmunity, allergy and their functions in the recognition and response to dead and cancerous cells.
Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalCurrent Opinion in Immunology
Volume32
Early online date29 Dec 2014
DOIs
Publication statusPublished - Feb 2015

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