Calcium channel subtypes and intracellular calcium stores modulate electric field-stimulated and -oriented nerve growth

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

In culture, embryonic spinal neurites from Xenopus laevis show striking growth responses to steady dc electric fields, at a time when endogenous electric fields of similar size impinge on the developing nervous system. A high proportion of cultured neurites reorient, with both turning and branching directed cathodally. Neurite growth rates are increased and growth is differential (faster cathodally than anodally). Voltage-dependent calcium channels and calcium release from intracellular stores are shown to control these events. However, the pharmacological sensitivities of these phenomena differ, indicating different control mechanisms.
Original languageEnglish
Pages (from-to)340-351
Number of pages12
JournalDevelopmental Biology
Volume171
Issue number2
DOIs
Publication statusPublished - 1 Oct 1995

Fingerprint

Neurites
Calcium Channels
Calcium
Growth
Xenopus laevis
Nervous System

Keywords

  • Animals
  • Calcium
  • Calcium Channel Blockers
  • Calcium Channels
  • Cells, Cultured
  • Electric Stimulation
  • Female
  • Neurites
  • Xenopus laevis

Cite this

@article{7dd11f30a1164f56874ffa991a1a5e20,
title = "Calcium channel subtypes and intracellular calcium stores modulate electric field-stimulated and -oriented nerve growth",
abstract = "In culture, embryonic spinal neurites from Xenopus laevis show striking growth responses to steady dc electric fields, at a time when endogenous electric fields of similar size impinge on the developing nervous system. A high proportion of cultured neurites reorient, with both turning and branching directed cathodally. Neurite growth rates are increased and growth is differential (faster cathodally than anodally). Voltage-dependent calcium channels and calcium release from intracellular stores are shown to control these events. However, the pharmacological sensitivities of these phenomena differ, indicating different control mechanisms.",
keywords = "Animals, Calcium, Calcium Channel Blockers, Calcium Channels, Cells, Cultured, Electric Stimulation, Female, Neurites, Xenopus laevis",
author = "R Stewart and Lynda Erskine and McCaig, {Colin Darnley}",
year = "1995",
month = "10",
day = "1",
doi = "10.1006/dbio.1995.1286",
language = "English",
volume = "171",
pages = "340--351",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Calcium channel subtypes and intracellular calcium stores modulate electric field-stimulated and -oriented nerve growth

AU - Stewart, R

AU - Erskine, Lynda

AU - McCaig, Colin Darnley

PY - 1995/10/1

Y1 - 1995/10/1

N2 - In culture, embryonic spinal neurites from Xenopus laevis show striking growth responses to steady dc electric fields, at a time when endogenous electric fields of similar size impinge on the developing nervous system. A high proportion of cultured neurites reorient, with both turning and branching directed cathodally. Neurite growth rates are increased and growth is differential (faster cathodally than anodally). Voltage-dependent calcium channels and calcium release from intracellular stores are shown to control these events. However, the pharmacological sensitivities of these phenomena differ, indicating different control mechanisms.

AB - In culture, embryonic spinal neurites from Xenopus laevis show striking growth responses to steady dc electric fields, at a time when endogenous electric fields of similar size impinge on the developing nervous system. A high proportion of cultured neurites reorient, with both turning and branching directed cathodally. Neurite growth rates are increased and growth is differential (faster cathodally than anodally). Voltage-dependent calcium channels and calcium release from intracellular stores are shown to control these events. However, the pharmacological sensitivities of these phenomena differ, indicating different control mechanisms.

KW - Animals

KW - Calcium

KW - Calcium Channel Blockers

KW - Calcium Channels

KW - Cells, Cultured

KW - Electric Stimulation

KW - Female

KW - Neurites

KW - Xenopus laevis

U2 - 10.1006/dbio.1995.1286

DO - 10.1006/dbio.1995.1286

M3 - Article

C2 - 7556918

VL - 171

SP - 340

EP - 351

JO - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

IS - 2

ER -