Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function

Urzula Wasik, Gabriela Schneider, Ann Mietelska-Porowska, Marcin Mazurkiewicz, Hanna Fabczak, Serge Weis, Claudia Zabke, Charles Robert Harrington, Anna Filipek, Grazyna Niewiadomska

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17 Citations (Scopus)

Abstract

The calcyclin binding protein and Siah-1 interacting protein (CacyBP/SIP) protein was shown to play a role in the organization of microtubules. In this work we have examined the neuronal distribution and possible function of CacyBP/SIP in cytoskeletal pathophysiology. We have used brain tissue from Alzheimer’s disease (AD) patients and from transgenic mice modeling 2 different pathologies characteristic for AD: amyloid and tau. In the brain from AD patients, CacyBP/SIP was found to be almost exclusively present in neuronal somata, and in control patients it was seen in the somata and neuronal processes. In mice doubly transgenic for amyloid precursor protein and presenilin 1 there was no difference in CacyBP/SIP neuronal localization in comparison with the nontransgenic animals. By contrast in tau transgenic mice, localization of CacyBP/SIP was similar to that observed for AD patients. To find the relation between CacyBP/SIP and tau we examined dephosphorylation of tau by CacyBP/SIP. We found that indeed it exhibited phosphatase activity toward tau. Altogether, our results suggest that CacyBP/SIP might play a role in AD pathology.
Original languageEnglish
Pages (from-to)1380-1388
Number of pages9
JournalNeurobiology of Aging
Volume34
Issue number5
Early online date20 Dec 2012
DOIs
Publication statusPublished - May 2013

Keywords

  • Alzheimer's disease (AD) CacyBP/SIP S100A6 Amyloidosis Tau mice Phosphatase activity

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    Wasik, U., Schneider, G., Mietelska-Porowska, A., Mazurkiewicz, M., Fabczak, H., Weis, S., Zabke, C., Harrington, C. R., Filipek, A., & Niewiadomska, G. (2013). Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function. Neurobiology of Aging, 34(5), 1380-1388. https://doi.org/10.1016/j.neurobiolaging.2012.11.007