Calorie-restricted mice that gorge show less ability to compensate for reduced energy intake

Catherine Hambly, Claire A. Simpson, Shona McIntosh, Jackie S. Duncan, Gillian D. Dalgleish, John R. Speakman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Caloric restriction in mice can trigger gorging behaviour, which is characterized by periods of excessive food ingestion in a short time. Animals that gorge are thought to have a reduced metabolism compared to those that nibble their food over a longer period and might therefore be more able to compensate for reduced energy intake. We examined whether mice that gorged showed less weigh loss during restriction.

We placed female mice (n =60) on a restriction of 75% of their ad libitum food intake (FI) for 22 days. FI and body mass (BM) were measured at 1, 2 and 24 h after food provision. Ten controls remained feeding ad lib and we selected the 10 strongest gorgers and 10 strongest non-gorgers for comparison. Mice had BM, FI, resting metabolic rate (RMR), body composition, body temperature, daily energy expenditure (DEE) and circulating levels of the regulatory hormones leptin and ghrelin measured.

Gorgers had a significantly lower BM at the end of restriction than non-gorgers or controls, indicating that they were less able to compensate for the reduced energy. Both groups of restricted mice had reduced RMR, however reduced activity was only used as an energy saving mechanism in non-gorgers. Gorging mice had a significantly lower level of circulating leptin than controls and non-gorgers but no differences in ghrelin levels. Gorging mice were, in fact, less able to compensate for reduced energy intake, as they reduced RMR by a similar extent as non-gorgers, but did not reduce activity compared to non-gorgers on the same restriction level. The reduced leptin levels may drive the gorging behaviour. (c) 2007 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)985-992
Number of pages8
JournalPhysiology and Behavior
Volume92
Issue number5
DOIs
Publication statusPublished - 5 Dec 2007

Keywords

  • gorging
  • resting metabolic rate
  • daily energy expenditure
  • activity
  • energy budget
  • food restriction
  • plasma ghrelin levels
  • Fischer-344 RATS
  • body-weight
  • food
  • expenditure
  • leptin
  • temperature
  • peptide

Cite this

Calorie-restricted mice that gorge show less ability to compensate for reduced energy intake. / Hambly, Catherine; Simpson, Claire A.; McIntosh, Shona; Duncan, Jackie S.; Dalgleish, Gillian D.; Speakman, John R.

In: Physiology and Behavior, Vol. 92, No. 5, 05.12.2007, p. 985-992.

Research output: Contribution to journalArticle

Hambly, Catherine ; Simpson, Claire A. ; McIntosh, Shona ; Duncan, Jackie S. ; Dalgleish, Gillian D. ; Speakman, John R. / Calorie-restricted mice that gorge show less ability to compensate for reduced energy intake. In: Physiology and Behavior. 2007 ; Vol. 92, No. 5. pp. 985-992.
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AU - Speakman, John R.

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AB - Caloric restriction in mice can trigger gorging behaviour, which is characterized by periods of excessive food ingestion in a short time. Animals that gorge are thought to have a reduced metabolism compared to those that nibble their food over a longer period and might therefore be more able to compensate for reduced energy intake. We examined whether mice that gorged showed less weigh loss during restriction.We placed female mice (n =60) on a restriction of 75% of their ad libitum food intake (FI) for 22 days. FI and body mass (BM) were measured at 1, 2 and 24 h after food provision. Ten controls remained feeding ad lib and we selected the 10 strongest gorgers and 10 strongest non-gorgers for comparison. Mice had BM, FI, resting metabolic rate (RMR), body composition, body temperature, daily energy expenditure (DEE) and circulating levels of the regulatory hormones leptin and ghrelin measured.Gorgers had a significantly lower BM at the end of restriction than non-gorgers or controls, indicating that they were less able to compensate for the reduced energy. Both groups of restricted mice had reduced RMR, however reduced activity was only used as an energy saving mechanism in non-gorgers. Gorging mice had a significantly lower level of circulating leptin than controls and non-gorgers but no differences in ghrelin levels. Gorging mice were, in fact, less able to compensate for reduced energy intake, as they reduced RMR by a similar extent as non-gorgers, but did not reduce activity compared to non-gorgers on the same restriction level. The reduced leptin levels may drive the gorging behaviour. (c) 2007 Elsevier Inc. All rights reserved.

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KW - expenditure

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