Campylobacter genotypes from food animals, environmental sources and clinical disease in Scotland 2005/6

Samuel K. Sheppard, John F Dallas, Marion MacRae, Noel D. McCarthy, E. L. Sproston, F. J. Gormley, Norval James Colin Strachan, Iain D Ogden, Martin C. J. Maiden, Ken J. Forbes

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

A nationwide multi-locus sequence typing (MLST) survey was implemented to analyze patterns of host association among Campylobacter jejuni and Campylobacter coli isolates from clinical disease in Scotland (July 2005-September 2006). food animals (chickens, cattle. sheep, pigs and turkey), non-food animals (wild birds) and the environment Sequence types (STs) were determined for 5247 clinical isolates and 999 from potential disease sources (augmented with 2420 published STs). Certain STs were over represented among particular sample sets/host groups. These host-associated STs were identified for all sample groups in both Campylobacter species and host associated clonal complexes (groups of related STs) were characterized for C jejuni. Some genealogical lineages were present in both human disease and food animal samples. This provided evidence for the relative importance of different infection routes/food animal sources in human disease. These results show robust associations of particular genotypes with potential infection sources supporting the contention that contaminated poultry is a major source of human disease. (C) 2009 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalInternational Journal of Food Microbiology
Volume134
Issue number1-2
Early online date20 Feb 2009
DOIs
Publication statusPublished - 31 Aug 2009

Keywords

  • MLST
  • Campylobacter jejuni
  • Campylobacter coli
  • Host association
  • sequence typing system
  • risk-factors
  • population-structure
  • quinolone resistance
  • JEJUNI infections
  • genetic diversity
  • Guillan-barre
  • coli
  • poultry
  • identification

Cite this

Campylobacter genotypes from food animals, environmental sources and clinical disease in Scotland 2005/6. / Sheppard, Samuel K.; Dallas, John F; MacRae, Marion; McCarthy, Noel D.; Sproston, E. L.; Gormley, F. J.; Strachan, Norval James Colin; Ogden, Iain D; Maiden, Martin C. J.; Forbes, Ken J.

In: International Journal of Food Microbiology, Vol. 134, No. 1-2, 31.08.2009, p. 96-103.

Research output: Contribution to journalArticle

Sheppard, Samuel K. ; Dallas, John F ; MacRae, Marion ; McCarthy, Noel D. ; Sproston, E. L. ; Gormley, F. J. ; Strachan, Norval James Colin ; Ogden, Iain D ; Maiden, Martin C. J. ; Forbes, Ken J. / Campylobacter genotypes from food animals, environmental sources and clinical disease in Scotland 2005/6. In: International Journal of Food Microbiology. 2009 ; Vol. 134, No. 1-2. pp. 96-103.
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