TY - JOUR
T1 - Can patients' likelihood of benefiting from primary chemotherapy for breast cancer be predicted before commencement of treatment?
AU - Ogston, Keith Nicholas
AU - Miller, Iain D
AU - Schofield, Andrew Craig
AU - Spyrantis, A.
AU - Pavlidou, E.
AU - Sarkar, T. K.
AU - Hutcheon, A. W.
AU - Payne, S.
AU - Heys, Steven Darryll
PY - 2004/7
Y1 - 2004/7
N2 - Purpose. Primary chemotherapy is commonly used in patients with breast cancer to downstage the primary tumour prior to surgery. There is a need to establish, prior to commencement of chemotherapy, predictors of clinical and pathological response, which may then be surrogate markers for patient survival and thus allow identification of patients who are most likely to benefit from such treatment.Patients and methods. A total of 104 patients with large and locally advanced breast cancers received an anthracycline/docetaxel-based regimen prior to surgery. Immunohistochemistry was carried out on pretreatment core biopsies of the tumour to detect hormone receptors (oestrogen-ER; progesterone-PR), a proliferation marker (MIB-1), the oncoprotein Bcl-2, an extracellular matrix degradation enzyme ( cathepsin D), p53, and an oestrogen associated protein (pS2). Both clinical and pathological response were assessed following completion of chemotherapy.Results. Patients whose tumours did not express oestrogen receptor ( p = 0.02) or did not express Bcl-2 (p< 0.01) had a better pathological response in a univariate analysis. However, in a multivariate model, it was only the absence of detectable Bcl-2 protein that predicted a better pathological response ( p = 0.001).Conclusions. This study has identified that patients whose breast cancers are most likely to experience the greatest degree of tumour destruction by primary chemotherapy do not express either oestrogen receptors or Bcl-2. This may have important implications in the selection of patients with breast cancer for primary chemotherapy who are most likely to gain a survival benefit.
AB - Purpose. Primary chemotherapy is commonly used in patients with breast cancer to downstage the primary tumour prior to surgery. There is a need to establish, prior to commencement of chemotherapy, predictors of clinical and pathological response, which may then be surrogate markers for patient survival and thus allow identification of patients who are most likely to benefit from such treatment.Patients and methods. A total of 104 patients with large and locally advanced breast cancers received an anthracycline/docetaxel-based regimen prior to surgery. Immunohistochemistry was carried out on pretreatment core biopsies of the tumour to detect hormone receptors (oestrogen-ER; progesterone-PR), a proliferation marker (MIB-1), the oncoprotein Bcl-2, an extracellular matrix degradation enzyme ( cathepsin D), p53, and an oestrogen associated protein (pS2). Both clinical and pathological response were assessed following completion of chemotherapy.Results. Patients whose tumours did not express oestrogen receptor ( p = 0.02) or did not express Bcl-2 (p< 0.01) had a better pathological response in a univariate analysis. However, in a multivariate model, it was only the absence of detectable Bcl-2 protein that predicted a better pathological response ( p = 0.001).Conclusions. This study has identified that patients whose breast cancers are most likely to experience the greatest degree of tumour destruction by primary chemotherapy do not express either oestrogen receptors or Bcl-2. This may have important implications in the selection of patients with breast cancer for primary chemotherapy who are most likely to gain a survival benefit.
KW - breast cancer
KW - primary chemotheraphy
KW - NEOADJUVANT CHEMOENDOCRINE THERAPY
KW - RANDOMIZED-TRIAL
KW - PREOPERATIVE CHEMOTHERAPY
KW - ADJUVANT CHEMOTHERAPY
KW - PROGNOSTIC-FACTORS
KW - P53
KW - MARKERS
KW - EXPRESSION
KW - DOCETAXEL
KW - CARCINOMA
U2 - 10.1023/B:BREA.0000032986.00879.d7
DO - 10.1023/B:BREA.0000032986.00879.d7
M3 - Article
SN - 0167-6806
VL - 86
SP - 181
EP - 189
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 2
ER -