Cancer

Paul Haggarty, Steven D. Heys

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The strongest evidence linking early nutrition to cancer in humans comes from randomized controlled trials but, for obvious ethical and practical reasons, there have been very few nutritional interventions in early life specifically designed to influence later cancer risk in the offspring. Much of the evidence for the programming of cancer risk and other health outcomes by early nutrition comes from studies in animals. Most of the evidence in humans to substantiate this link comes from observational data, primarily associations between birthweight and early growth and adult disease. There are numerous hypothesised mechanisms through which nutrition can influence the risk of cancer. Critically, any postulated mechanism linking early nutrition to cancer risk must explain the delay, often of decades, between the original exposure and manifestation of the disease. Likely hypotheses can be categorised into effects on genotype, epigenotype and phenotype.
Original languageEnglish
Title of host publicationNutrition and Development
Subtitle of host publicationShort- and Long-Term Consequences for Health
EditorsJudith L. Buttriss, British Nutrition Foundation
Place of PublicationLondon
PublisherWiley-Blackwell
Pages164-176
Number of pages13
ISBN (Electronic)9781118782972
ISBN (Print)978-1444336788
DOIs
Publication statusPublished - 31 May 2013

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    Haggarty, P., & Heys, S. D. (2013). Cancer. In J. L. Buttriss, & British Nutrition Foundation (Eds.), Nutrition and Development: Short- and Long-Term Consequences for Health (pp. 164-176). Wiley-Blackwell . https://doi.org/10.1002/9781118782972.ch11