Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole

Betty Wächtler, Duncan Wilson, Bernhard Hube

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Clotrimazole and bifonazole are highly effective antifungal agents against mucosal Candida albicans infections. Here we examined the effects of low levels of clotrimazole and bifonazole on the ability of C. albicans to adhere, invade, and damage vaginal epithelial cells. Although adhesion and invasion were not affected, damage was greatly reduced upon azole treatment. This clearly indicates that low levels of azoles influence specific activities of C. albicans during distinct stages of vaginal epithelium infections.
Original languageEnglish
Pages (from-to)4436-4439
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • antifungal agents
  • Candida albicans
  • cell line
  • clotrimazole
  • enzyme-linked immunosorbent assay
  • epithelial cells
  • female
  • humans
  • imidazoles
  • vagina

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