Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity

Simon Vautier, Rebecca A Drummond, Kong Chen, Graeme I Murray, David Kadosh, Alistair J P Brown, Neil A R Gow, Donna M MacCallum, Jay K Kolls, Gordon D Brown

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Abstract

The ability of Candida albicans to cause disease is associated with its capacity to undergo morphological transition between yeast and filamentous forms, but the role of morphology in colonisation and dissemination from the gastrointestinal (GI) tract remains poorly defined. To explore this, we made use of wild type and morphological mutants of C. albicans in an established model of GI tract colonization, induced following antibiotic-treatment of mice. Our data reveal that GI tract colonization favours the yeast form of C. albicans, that there is constitutive low level systemic dissemination in colonized mice that occurs irrespective of fungal morphology, and that colonization is not controlled by Th17 immunity in otherwise immunocompetent animals. These data provide new insights into the mechanisms of pathogenesis and commensalism of C. albicans, and have implications for our understanding of human disease.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalCellular Microbiology
Volume17
Issue number4
Early online date25 Nov 2014
DOIs
Publication statusPublished - Apr 2015

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