Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 119-128 |
| Number of pages | 10 |
| Journal | Virulence |
| Volume | 4 |
| Issue number | 2 |
| Early online date | 9 Jan 2013 |
| DOIs | |
| Publication status | Published - 15 Feb 2013 |
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Keywords
- Candida albicans
- Candidiasis
- Humans
- Virulence Factors
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Candida albicans pathogenicity mechanisms. / Mayer, François L; Wilson, Duncan; Hube, Bernhard.
In: Virulence, Vol. 4, No. 2, 15.02.2013, p. 119-128.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Candida albicans pathogenicity mechanisms
AU - Mayer, François L
AU - Wilson, Duncan
AU - Hube, Bernhard
PY - 2013/2/15
Y1 - 2013/2/15
N2 - The polymorphic fungus Candida albicans is a member of the normal human microbiome. In most individuals, C. albicans resides as a lifelong, harmless commensal. Under certain circumstances, however, C. albicans can cause infections that range from superficial infections of the skin to life-threatening systemic infections. Several factors and activities have been identified which contribute to the pathogenic potential of this fungus. Among them are molecules which mediate adhesion to and invasion into host cells, the secretion of hydrolases, the yeast-to-hypha transition, contact sensing and thigmotropism, biofilm formation, phenotypic switching and a range of fitness attributes. Our understanding of when and how these mechanisms and factors contribute to infection has significantly increased during the last years. In addition, novel virulence mechanisms have recently been discovered. In this review we present an update on our current understanding of the pathogenicity mechanisms of this important human pathogen.
AB - The polymorphic fungus Candida albicans is a member of the normal human microbiome. In most individuals, C. albicans resides as a lifelong, harmless commensal. Under certain circumstances, however, C. albicans can cause infections that range from superficial infections of the skin to life-threatening systemic infections. Several factors and activities have been identified which contribute to the pathogenic potential of this fungus. Among them are molecules which mediate adhesion to and invasion into host cells, the secretion of hydrolases, the yeast-to-hypha transition, contact sensing and thigmotropism, biofilm formation, phenotypic switching and a range of fitness attributes. Our understanding of when and how these mechanisms and factors contribute to infection has significantly increased during the last years. In addition, novel virulence mechanisms have recently been discovered. In this review we present an update on our current understanding of the pathogenicity mechanisms of this important human pathogen.
KW - Candida albicans
KW - Candidiasis
KW - Humans
KW - Virulence Factors
U2 - 10.4161/viru.22913
DO - 10.4161/viru.22913
M3 - Article
C2 - 23302789
VL - 4
SP - 119
EP - 128
JO - Virulence
JF - Virulence
SN - 2150-5594
IS - 2
ER -