Cannabinoid pharmacology

Research output: Contribution to journalArticle

363 Citations (Scopus)

Abstract

Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB1 and CB2 receptors and of endogenous ligands for these receptors, to the development of CB1- and CB2-selective agonists and antagonists and to the realization that the endogenous cannabinoid system has significant roles in both health and disease, and that drugs Which mimic, augment or block the actions of endogenously released cannabinoids must have important therapeutic applications. Some goals for future research are identified.

Original languageEnglish
Pages (from-to)S163-S171
Number of pages9
JournalBritish Journal of Pharmacology
Volume147
Issue numberS1
DOIs
Publication statusPublished - Jan 2006

Keywords

  • cannabis
  • cannabinoids
  • endocannabinoids
  • cannabinoid receptor agonists
  • cannabinoid receptor antagonists
  • anandamide
  • 2-arachidonoyl glycerol
  • autoprotection
  • autoimpairment
  • RECEPTOR
  • ANANDAMIDE
  • METABOLISM
  • MECHANISMS
  • POTENT
  • CB1
  • cannabis
  • cannabinoids
  • endocannabinoids
  • cannabinoid receptor agonists
  • cannabinoid receptor antagonists
  • anandamide
  • 2-arachidonoyl glycerol
  • autoprotection

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