Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation

A S Douglas, S P Robins, J D Hutchison, R W Porter, A Stewart, D M Reid

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The effect of vitamin supplements on bone metabolism indices in patients with osteoporosis has received scant attention in the literature. Over a 2-week period, vitamin supplements of K and K+D were given to 20 post-menopausal osteoporotic women with previous Colles fractures. Osteoporosis was confirmed by bone mass measurements that demonstrated that broadband ultrasound attenuation (os calcis) was almost as discriminatory as dual energy X-ray absorptiometry (spine and hip) in Colles fracture patients compared with matched controls. Vitamin K corrected the carboxylation defect in osteocalcin and while less marked 4 weeks later, the improvement was still detectable. The result after K+D was similar. The level of carboxylation became the same as in premenopausal women. Total osteocalcin level (bound) osteocalcin. While there was vitamin K correctable undercarboxylation of osteocalcin, simultaneously there was no evidence of undercarboxylation of prothrombin.
Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalBone
Volume17
Issue number1
Publication statusPublished - 1995

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Vitamin K
Osteocalcin
Vitamin D
Colles' Fracture
Osteoporosis
Bone and Bones
Photon Absorptiometry
Prothrombin
Vitamins
Hip
Spine

Keywords

  • Absorptiometry, Photon
  • Adult
  • Aged
  • Biological Markers
  • Bone Density
  • Colles' Fracture
  • Cross-Over Studies
  • Female
  • Femur
  • Humans
  • Middle Aged
  • Osteocalcin
  • Osteoporosis, Postmenopausal
  • Premenopause
  • Protein Precursors
  • Prothrombin
  • ROC Curve
  • Single-Blind Method
  • Spinal Canal
  • Vitamin D
  • Vitamin K

Cite this

Douglas, A. S., Robins, S. P., Hutchison, J. D., Porter, R. W., Stewart, A., & Reid, D. M. (1995). Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation. Bone, 17(1), 15-20.

Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation. / Douglas, A S; Robins, S P; Hutchison, J D; Porter, R W; Stewart, A; Reid, D M.

In: Bone, Vol. 17, No. 1, 1995, p. 15-20.

Research output: Contribution to journalArticle

Douglas, AS, Robins, SP, Hutchison, JD, Porter, RW, Stewart, A & Reid, DM 1995, 'Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation', Bone, vol. 17, no. 1, pp. 15-20.
Douglas AS, Robins SP, Hutchison JD, Porter RW, Stewart A, Reid DM. Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation. Bone. 1995;17(1):15-20.
Douglas, A S ; Robins, S P ; Hutchison, J D ; Porter, R W ; Stewart, A ; Reid, D M. / Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation. In: Bone. 1995 ; Vol. 17, No. 1. pp. 15-20.
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AU - Douglas, A S

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AU - Porter, R W

AU - Stewart, A

AU - Reid, D M

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N2 - The effect of vitamin supplements on bone metabolism indices in patients with osteoporosis has received scant attention in the literature. Over a 2-week period, vitamin supplements of K and K+D were given to 20 post-menopausal osteoporotic women with previous Colles fractures. Osteoporosis was confirmed by bone mass measurements that demonstrated that broadband ultrasound attenuation (os calcis) was almost as discriminatory as dual energy X-ray absorptiometry (spine and hip) in Colles fracture patients compared with matched controls. Vitamin K corrected the carboxylation defect in osteocalcin and while less marked 4 weeks later, the improvement was still detectable. The result after K+D was similar. The level of carboxylation became the same as in premenopausal women. Total osteocalcin level (bound) osteocalcin. While there was vitamin K correctable undercarboxylation of osteocalcin, simultaneously there was no evidence of undercarboxylation of prothrombin.

AB - The effect of vitamin supplements on bone metabolism indices in patients with osteoporosis has received scant attention in the literature. Over a 2-week period, vitamin supplements of K and K+D were given to 20 post-menopausal osteoporotic women with previous Colles fractures. Osteoporosis was confirmed by bone mass measurements that demonstrated that broadband ultrasound attenuation (os calcis) was almost as discriminatory as dual energy X-ray absorptiometry (spine and hip) in Colles fracture patients compared with matched controls. Vitamin K corrected the carboxylation defect in osteocalcin and while less marked 4 weeks later, the improvement was still detectable. The result after K+D was similar. The level of carboxylation became the same as in premenopausal women. Total osteocalcin level (bound) osteocalcin. While there was vitamin K correctable undercarboxylation of osteocalcin, simultaneously there was no evidence of undercarboxylation of prothrombin.

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