Carcinogenicity assessment using biosensors: Mitomycin-C as a case study

H. A. Alhadrami, G. I. Paton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study enabled an empirical assessment of a model carcinogen and its potency on human receptors. SOS-lux biosensors had numerous practical advantages over the traditional assays including procedural simplicity, ease of measurement and in vivo analysis without cell disruption. A key advantage of the application of biosensors is their ability to be deployed to genuine samples. This means that while chromatographic analysis requires extraction, purification, clean-up and then analysis, the biosensor can be used in crude and turbid solutions. This could be exclusively for a carcinogenic sensor or for a wider suite of sensors for specific analytes and generic toxicity. Samples could be exposed to a suite of sensors simultaneously allowing a real time response that could prove valuable for the protection of target receptors at a timescale commensurate with intervention. The data presented confirm that the sensors could be fabricated to permit compact analysis and the use of disposable electrodes. Such technologies could transform routine testing and interpretation.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014
PublisherNano Science and Technology Institute
Pages207-210
Number of pages4
Volume2
ISBN (Print)9781482258271
Publication statusPublished - 2014
EventNanotechnology 2014: MEMS, Fluidics, Bio Systems, Medical, Computational and Photonics - 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014 - Washington, DC, United States
Duration: 15 Jun 201418 Jun 2014

Conference

ConferenceNanotechnology 2014: MEMS, Fluidics, Bio Systems, Medical, Computational and Photonics - 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014
CountryUnited States
CityWashington, DC
Period15/06/1418/06/14

Keywords

  • Bioluminescent bacteria
  • In vitro digestion
  • Mutagenicity
  • Salmonella assay
  • Sos-lux biosensors

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials

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    Oceanlab Business Unit

    Neil Gregge (Manager)

    Aberdeen Centre For Environmental Sustainability

    Research Facilities: Facility

  • Cite this

    Alhadrami, H. A., & Paton, G. I. (2014). Carcinogenicity assessment using biosensors: Mitomycin-C as a case study. In Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014 (Vol. 2, pp. 207-210). Nano Science and Technology Institute.