Cardiac Energetic Impairment in Heart Disease and the Potential Role of Metabolic Modulators: A Review for Clinicians

Satnam Singh, Konstantin Schwarz, John Horowitz, Michael Frenneaux*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Cardiac energetic impairment is a frequent finding in patients with both inherited and acquired diseases of heart muscle. In this review the mechanisms of energy generation in the healthy heart and their disturbances in heart muscle diseases are described. Therapeutic agents targeted at correcting cardiac energetic impairment are discussed.

Original languageEnglish
Pages (from-to)720-728
Number of pages9
JournalCirculation. Cardiovascular Genetics
Issue number5
Publication statusPublished - Oct 2014


  • drug therapy
  • energy metabolism
  • perhexiline
  • reperfusion injury
  • fatty-acid oxidation
  • idiopathic dilated cardiomyopathy
  • left-ventricular performance
  • coenzyme-A decarboxylase
  • failing human heart
  • glucose-oxidation
  • creatine-kinase
  • hypertrophic cardiomyopathy
  • uncoupling proteins
  • double-blind

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