CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations

Georgina Louise Hold, Charles S. Rabkin, Marilie D. Gammon, Susan Helen Berry, Malcolm G Smith, Jolanta Lissowska, Harvey A. Risch, Wong-Ho Chow, Ashley G Mowat, Thomas L. Vaughan, Emad Munir El-Omar

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Abstract

Host genetic factors play an important role in modifying the risk of human disease, including cancers of the upper gastrointestinal tract, with increasing interest in Toll-like receptor (TLR) signaling and the impact of genetic polymorphisms in these systems. The CD14-159C/T and the TLR9-1237T/C promoter polymorphisms have previously been shown to be associated with various inflammatory conditions including Helicobacter pylori-induced gastritis in Caucasian populations. In this study, we assessed the association of these two functional single nucleotide polymorphisms with gastric cancer in two independent Caucasian population-based case-control studies of upper gastrointestinal tract cancer, initially in 312 noncardia gastric carcinoma cases and 419 controls and then in 184 noncardia gastric carcinomas, 123 cardia carcinomas, 159 esophageal cancers, and 211 frequency-matched controls. Odds ratios were computed from logistic models and adjusted for potential confounding factors. No significant association was found between the CD14-159C/T and the TLR9-1237T/C promoter polymorphisms and increased risk of gastric cancer, Neither single nucleotide polymorphism has been assessed in a Caucasian gastric cancer case-control study before; although the CD14-159C/T polymorphism has been reported to show no apparent association with H. pylori-related gastric malignancy in a Taiwanese Chinese population. In conclusion, although our earlier preliminary studies suggested that the CD14-159C/T and the TLR9-1237T/C promoter polymorphisms increase the risk of precancerous outcomes, they do not seem to increase the risk of gastric cancer itself. This discrepancy merits further examination. European Journal of Cancer Prevention 18:117-119 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Original languageEnglish
Pages (from-to)117-119
Number of pages3
JournalEuropean Journal of Cancer Prevention
Volume18
Issue number2
DOIs
Publication statusPublished - Apr 2009

Keywords

  • gastric cancer
  • Helicobacter pylori-induced disease
  • innate immunity
  • polymorphisms
  • Toll-like receptor signaling pathways
  • bacterial-DNA
  • CD14 gene
  • TLR9
  • toll-like-receptor-4
  • expression
  • carcinoma
  • promoter
  • alcohol
  • disease

Cite this

Hold, G. L., Rabkin, C. S., Gammon, M. D., Berry, S. H., Smith, M. G., Lissowska, J., ... El-Omar, E. M. (2009). CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations. European Journal of Cancer Prevention, 18(2), 117-119. https://doi.org/10.1097/CEJ.0b013e3283101292