Cell division and death inhibit glassy behaviour of confluent tissues

D. A. Matoz-Fernandez, K. Martens, Rastko Sknepnek, J. L. Barrat, S. Henkes

Research output: Contribution to journalArticle

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Abstract

We investigate the effects of cell division and apopotosis on collective dynamics in two-dimensional epithelial tissues. Our model includes three key ingredients observed across many epithelia, namely cell-cell adhesion, cell death and a cell division process that depends on the surrounding environment. We show a rich non-equilibrium phase diagram depending on the ratio of cell death to cell division and on the adhesion strength. For large apopotosis rates, cells die out and the tissue disintegrates. As the death rate decreases, however, we show, consecutively, the existence of a gas-like phase, a gel-like phase, and a dense confluent (tissue) phase. Most striking is the observation that the tissue is self-melting through its own internal activity, ruling out the existence of any glassy phase.
Original languageEnglish
Pages (from-to) 3205-3212
Number of pages7
JournalSoft matter
Volume13
Early online date3 Apr 2017
DOIs
Publication statusPublished - 2017

Fingerprint

cell division
death
Cells
Tissue
Cell death
adhesion
cells
epithelium
Bond strength (materials)
Cell adhesion
ingredients
Phase diagrams
Melting
Gases
Gels
phase diagrams
melting
gels
vapor phases

Keywords

  • cond-mat.soft
  • physics.bio-ph

Cite this

Matoz-Fernandez, D. A., Martens, K., Sknepnek, R., Barrat, J. L., & Henkes, S. (2017). Cell division and death inhibit glassy behaviour of confluent tissues. Soft matter, 13, 3205-3212. https://doi.org/10.1039/c6sm02580c

Cell division and death inhibit glassy behaviour of confluent tissues. / Matoz-Fernandez, D. A.; Martens, K.; Sknepnek, Rastko; Barrat, J. L.; Henkes, S.

In: Soft matter, Vol. 13, 2017, p. 3205-3212.

Research output: Contribution to journalArticle

Matoz-Fernandez, DA, Martens, K, Sknepnek, R, Barrat, JL & Henkes, S 2017, 'Cell division and death inhibit glassy behaviour of confluent tissues', Soft matter, vol. 13, pp. 3205-3212. https://doi.org/10.1039/c6sm02580c
Matoz-Fernandez DA, Martens K, Sknepnek R, Barrat JL, Henkes S. Cell division and death inhibit glassy behaviour of confluent tissues. Soft matter. 2017;13: 3205-3212. https://doi.org/10.1039/c6sm02580c
Matoz-Fernandez, D. A. ; Martens, K. ; Sknepnek, Rastko ; Barrat, J. L. ; Henkes, S. / Cell division and death inhibit glassy behaviour of confluent tissues. In: Soft matter. 2017 ; Vol. 13. pp. 3205-3212.
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