Cell division and death inhibit glassy behaviour of confluent tissues

D. A. Matoz-Fernandez; K. Martens; Rastko Sknepnek; J. L. Barrat; S. Henkes

doi:10.1039/c6sm02580c

Cell division and death inhibit glassy behaviour of confluent tissues

D. A. Matoz-Fernandez, K. Martens, Rastko Sknepnek, J. L. Barrat, S. Henkes

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Abstract

We investigate the effects of cell division and apopotosis on collective dynamics in two-dimensional epithelial tissues. Our model includes three key ingredients observed across many epithelia, namely cell-cell adhesion, cell death and a cell division process that depends on the surrounding environment. We show a rich non-equilibrium phase diagram depending on the ratio of cell death to cell division and on the adhesion strength. For large apopotosis rates, cells die out and the tissue disintegrates. As the death rate decreases, however, we show, consecutively, the existence of a gas-like phase, a gel-like phase, and a dense confluent (tissue) phase. Most striking is the observation that the tissue is self-melting through its own internal activity, ruling out the existence of any glassy phase.

Original language	English
Pages (from-to)	3205-3212
Number of pages	7
Journal	Soft matter
Volume	13
Early online date	3 Apr 2017
DOIs	https://doi.org/10.1039/c6sm02580c
Publication status	Published - 2017

Bibliographical note

D. M.-F. and J.-L. B. acknowledge financial support from ERC grant ADG20110209 and NVIDIA Corporation through Academic Partnership Program. K.M. thanks grant ANR-14-CE32-0005 of the French Agence Nationale de la Recherche. SH and RS would like to thank Prof Inke Nathke and Prof Kees Weijer for many illuminated discussion on biology of developing tissues. RS acknowledges support by the UK EPSRC (award EP/M009599/1) and BBSRC (award BB/N009789/1). SH acknowledges support by the CPTGA visiting researcher fund that allowed her to spend time in Grenoble and the BBSRC (award BB/N009150/1).

Keywords

cond-mat.soft
physics.bio-ph

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Cell division and death inhibit glassy behaviour of confluent tissues
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Cite this

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title = "Cell division and death inhibit glassy behaviour of confluent tissues",

abstract = "We investigate the effects of cell division and apopotosis on collective dynamics in two-dimensional epithelial tissues. Our model includes three key ingredients observed across many epithelia, namely cell-cell adhesion, cell death and a cell division process that depends on the surrounding environment. We show a rich non-equilibrium phase diagram depending on the ratio of cell death to cell division and on the adhesion strength. For large apopotosis rates, cells die out and the tissue disintegrates. As the death rate decreases, however, we show, consecutively, the existence of a gas-like phase, a gel-like phase, and a dense confluent (tissue) phase. Most striking is the observation that the tissue is self-melting through its own internal activity, ruling out the existence of any glassy phase.",

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note = "D. M.-F. and J.-L. B. acknowledge financial support from ERC grant ADG20110209 and NVIDIA Corporation through Academic Partnership Program. K.M. thanks grant ANR-14-CE32-0005 of the French Agence Nationale de la Recherche. SH and RS would like to thank Prof Inke Nathke and Prof Kees Weijer for many illuminated discussion on biology of developing tissues. RS acknowledges support by the UK EPSRC (award EP/M009599/1) and BBSRC (award BB/N009789/1). SH acknowledges support by the CPTGA visiting researcher fund that allowed her to spend time in Grenoble and the BBSRC (award BB/N009150/1).",

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T1 - Cell division and death inhibit glassy behaviour of confluent tissues

AU - Matoz-Fernandez, D. A.

AU - Martens, K.

AU - Sknepnek, Rastko

AU - Barrat, J. L.

AU - Henkes, S.

N1 - D. M.-F. and J.-L. B. acknowledge financial support from ERC grant ADG20110209 and NVIDIA Corporation through Academic Partnership Program. K.M. thanks grant ANR-14-CE32-0005 of the French Agence Nationale de la Recherche. SH and RS would like to thank Prof Inke Nathke and Prof Kees Weijer for many illuminated discussion on biology of developing tissues. RS acknowledges support by the UK EPSRC (award EP/M009599/1) and BBSRC (award BB/N009789/1). SH acknowledges support by the CPTGA visiting researcher fund that allowed her to spend time in Grenoble and the BBSRC (award BB/N009150/1).

PY - 2017

Y1 - 2017

N2 - We investigate the effects of cell division and apopotosis on collective dynamics in two-dimensional epithelial tissues. Our model includes three key ingredients observed across many epithelia, namely cell-cell adhesion, cell death and a cell division process that depends on the surrounding environment. We show a rich non-equilibrium phase diagram depending on the ratio of cell death to cell division and on the adhesion strength. For large apopotosis rates, cells die out and the tissue disintegrates. As the death rate decreases, however, we show, consecutively, the existence of a gas-like phase, a gel-like phase, and a dense confluent (tissue) phase. Most striking is the observation that the tissue is self-melting through its own internal activity, ruling out the existence of any glassy phase.

AB - We investigate the effects of cell division and apopotosis on collective dynamics in two-dimensional epithelial tissues. Our model includes three key ingredients observed across many epithelia, namely cell-cell adhesion, cell death and a cell division process that depends on the surrounding environment. We show a rich non-equilibrium phase diagram depending on the ratio of cell death to cell division and on the adhesion strength. For large apopotosis rates, cells die out and the tissue disintegrates. As the death rate decreases, however, we show, consecutively, the existence of a gas-like phase, a gel-like phase, and a dense confluent (tissue) phase. Most striking is the observation that the tissue is self-melting through its own internal activity, ruling out the existence of any glassy phase.

KW - cond-mat.soft

KW - physics.bio-ph

U2 - 10.1039/c6sm02580c

DO - 10.1039/c6sm02580c

M3 - Article

SN - 1744-683X

VL - 13

SP - 3205

EP - 3212

JO - Soft matter

JF - Soft matter

ER -

Cell division and death inhibit glassy behaviour of confluent tissues

Abstract

Bibliographical note

Keywords

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