Cell division and death inhibit glassy behaviour of confluent tissues

D. A. Matoz-Fernandez, K. Martens, Rastko Sknepnek, J. L. Barrat, S. Henkes

Research output: Contribution to journalArticle

15 Citations (Scopus)
12 Downloads (Pure)

Abstract

We investigate the effects of cell division and apopotosis on collective dynamics in two-dimensional epithelial tissues. Our model includes three key ingredients observed across many epithelia, namely cell-cell adhesion, cell death and a cell division process that depends on the surrounding environment. We show a rich non-equilibrium phase diagram depending on the ratio of cell death to cell division and on the adhesion strength. For large apopotosis rates, cells die out and the tissue disintegrates. As the death rate decreases, however, we show, consecutively, the existence of a gas-like phase, a gel-like phase, and a dense confluent (tissue) phase. Most striking is the observation that the tissue is self-melting through its own internal activity, ruling out the existence of any glassy phase.
Original languageEnglish
Pages (from-to) 3205-3212
Number of pages7
JournalSoft matter
Volume13
Early online date3 Apr 2017
DOIs
Publication statusPublished - 2017

Keywords

  • cond-mat.soft
  • physics.bio-ph

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