Cellular and molecular mechanisms of action of bisphosphonates

M J Rogers; Sharon Andrea Gordon; H L Benford; Fraser Coxon; S P Luckman; J Monkkonen; J C Frith

doi:10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.3.CO;2-C

Cellular and molecular mechanisms of action of bisphosphonates

M J Rogers, Sharon Andrea Gordon, H L Benford, Fraser Coxon, S P Luckman, J Monkkonen, J C Frith

Research output: Contribution to journal › Article › peer-review

875 Citations (Scopus)

Abstract

Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, where they appear to be internalized selectively by bone-resorbing osteoclasts and inhibit osteoclast function.

Original language	English
Pages (from-to)	2961-2978
Number of pages	18
Journal	Cancer
Volume	88
Issue number	12
DOIs	https://doi.org/10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.3.CO;2-C
Publication status	Published - 2000

Keywords

Animals
Bone Resorption
Bone and Bones
Diphosphonates
Humans
Osteoblasts
Osteoclasts
Protein Prenylation
Protein Tyrosine Phosphatases
Proton-Translocating ATPases
Structure-Activity Relationship

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10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.3.CO;2-C

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title = "Cellular and molecular mechanisms of action of bisphosphonates",

abstract = "Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, where they appear to be internalized selectively by bone-resorbing osteoclasts and inhibit osteoclast function.",

keywords = "Animals, Bone Resorption, Bone and Bones, Diphosphonates, Humans, Osteoblasts, Osteoclasts, Protein Prenylation, Protein Tyrosine Phosphatases, Proton-Translocating ATPases, Structure-Activity Relationship",

author = "Rogers, {M J} and Gordon, {Sharon Andrea} and Benford, {H L} and Fraser Coxon and Luckman, {S P} and J Monkkonen and Frith, {J C}",

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journal = "Cancer",

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TY - JOUR

T1 - Cellular and molecular mechanisms of action of bisphosphonates

AU - Rogers, M J

AU - Gordon, Sharon Andrea

AU - Benford, H L

AU - Coxon, Fraser

AU - Luckman, S P

AU - Monkkonen, J

AU - Frith, J C

PY - 2000

Y1 - 2000

N2 - Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, where they appear to be internalized selectively by bone-resorbing osteoclasts and inhibit osteoclast function.

AB - Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, where they appear to be internalized selectively by bone-resorbing osteoclasts and inhibit osteoclast function.

KW - Animals

KW - Bone Resorption

KW - Bone and Bones

KW - Diphosphonates

KW - Humans

KW - Osteoblasts

KW - Osteoclasts

KW - Protein Prenylation

KW - Protein Tyrosine Phosphatases

KW - Proton-Translocating ATPases

KW - Structure-Activity Relationship

U2 - 10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.3.CO;2-C

DO - 10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.3.CO;2-C

M3 - Article

C2 - 10898340

SN - 0008-543X

VL - 88

SP - 2961

EP - 2978

JO - Cancer

JF - Cancer

IS - 12

ER -

Cellular and molecular mechanisms of action of bisphosphonates

Abstract

Keywords

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