Cellular and molecular mechanisms of action of bisphosphonates

M J Rogers, Sharon Andrea Gordon, H L Benford, Fraser Coxon, S P Luckman, J Monkkonen, J C Frith

Research output: Contribution to journalArticle

800 Citations (Scopus)

Abstract

Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, where they appear to be internalized selectively by bone-resorbing osteoclasts and inhibit osteoclast function.
Original languageEnglish
Pages (from-to)2961-2978
Number of pages18
JournalCancer
Volume88
Issue number12
DOIs
Publication statusPublished - 2000

Fingerprint

Diphosphonates
Osteoclasts
Bone Density Conservation Agents
Bone and Bones
Osteolysis
Metabolic Bone Diseases
Hypercalcemia
Osteoporosis
Minerals
Calcium
Neoplasms

Keywords

  • Animals
  • Bone Resorption
  • Bone and Bones
  • Diphosphonates
  • Humans
  • Osteoblasts
  • Osteoclasts
  • Protein Prenylation
  • Protein Tyrosine Phosphatases
  • Proton-Translocating ATPases
  • Structure-Activity Relationship

Cite this

Rogers, M. J., Gordon, S. A., Benford, H. L., Coxon, F., Luckman, S. P., Monkkonen, J., & Frith, J. C. (2000). Cellular and molecular mechanisms of action of bisphosphonates. Cancer, 88(12 ), 2961-2978. https://doi.org/10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.3.CO;2-C

Cellular and molecular mechanisms of action of bisphosphonates. / Rogers, M J; Gordon, Sharon Andrea; Benford, H L; Coxon, Fraser; Luckman, S P; Monkkonen, J; Frith, J C.

In: Cancer, Vol. 88, No. 12 , 2000, p. 2961-2978.

Research output: Contribution to journalArticle

Rogers, MJ, Gordon, SA, Benford, HL, Coxon, F, Luckman, SP, Monkkonen, J & Frith, JC 2000, 'Cellular and molecular mechanisms of action of bisphosphonates', Cancer, vol. 88, no. 12 , pp. 2961-2978. https://doi.org/10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.3.CO;2-C
Rogers MJ, Gordon SA, Benford HL, Coxon F, Luckman SP, Monkkonen J et al. Cellular and molecular mechanisms of action of bisphosphonates. Cancer. 2000;88(12 ):2961-2978. https://doi.org/10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.3.CO;2-C
Rogers, M J ; Gordon, Sharon Andrea ; Benford, H L ; Coxon, Fraser ; Luckman, S P ; Monkkonen, J ; Frith, J C. / Cellular and molecular mechanisms of action of bisphosphonates. In: Cancer. 2000 ; Vol. 88, No. 12 . pp. 2961-2978.
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