Cellular and molecular mechanisms of action of bisphosphonates

M J Rogers, Sharon Andrea Gordon, H L Benford, Fraser Coxon, S P Luckman, J Monkkonen, J C Frith

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811 Citations (Scopus)

Abstract

Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, where they appear to be internalized selectively by bone-resorbing osteoclasts and inhibit osteoclast function.
Original languageEnglish
Pages (from-to)2961-2978
Number of pages18
JournalCancer
Volume88
Issue number12
DOIs
Publication statusPublished - 2000

Keywords

  • Animals
  • Bone Resorption
  • Bone and Bones
  • Diphosphonates
  • Humans
  • Osteoblasts
  • Osteoclasts
  • Protein Prenylation
  • Protein Tyrosine Phosphatases
  • Proton-Translocating ATPases
  • Structure-Activity Relationship

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  • Cite this

    Rogers, M. J., Gordon, S. A., Benford, H. L., Coxon, F., Luckman, S. P., Monkkonen, J., & Frith, J. C. (2000). Cellular and molecular mechanisms of action of bisphosphonates. Cancer, 88(12 ), 2961-2978. https://doi.org/10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.3.CO;2-C