Cellular Defense System Gene Expression Profiling of Human Whole Blood

Opportunities to Predict Health Benefits in Response to Diet

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Diet is a critical factor in the maintenance of human cellular defense systems, immunity, inflammation, redox regulation, metabolism, and DNA repair that ensure optimal health and reduce disease risk. Assessment of dietary modulation of cellular defense systems in humans has been limited due to difficulties in accessing target tissues. Notably, peripheral blood gene expression profiles associated with nonhematologic disease are detectable. Coupled with recent innovations in gene expression technologies, gene expression profiling of human blood to determine predictive markers associated with health status and dietary modulation is now a feasible prospect for nutrition scientists. This review focuses on cellular defense system gene expression profiling of human whole blood and the opportunities this presents, using recent technological advances, to predict health status and benefits conferred by diet.

Original languageEnglish
Pages (from-to)499-505
Number of pages7
JournalAdvances in Nutrition
Volume3
Issue number4
DOIs
Publication statusPublished - 1 Jul 2012

Fingerprint

Gene Expression Profiling
Insurance Benefits
Diet
gene expression
blood
health status
diet
Health Status
DNA repair
Transcriptome
DNA Repair
Oxidation-Reduction
Immunity
immunity
inflammation
nutrition
Inflammation
Technology
Gene Expression
metabolism

Cite this

@article{315a3d1466914b1c8e83d0b196e67cf8,
title = "Cellular Defense System Gene Expression Profiling of Human Whole Blood: Opportunities to Predict Health Benefits in Response to Diet",
abstract = "Diet is a critical factor in the maintenance of human cellular defense systems, immunity, inflammation, redox regulation, metabolism, and DNA repair that ensure optimal health and reduce disease risk. Assessment of dietary modulation of cellular defense systems in humans has been limited due to difficulties in accessing target tissues. Notably, peripheral blood gene expression profiles associated with nonhematologic disease are detectable. Coupled with recent innovations in gene expression technologies, gene expression profiling of human blood to determine predictive markers associated with health status and dietary modulation is now a feasible prospect for nutrition scientists. This review focuses on cellular defense system gene expression profiling of human whole blood and the opportunities this presents, using recent technological advances, to predict health status and benefits conferred by diet.",
author = "Janice Drew",
year = "2012",
month = "7",
day = "1",
doi = "10.3945/an.112.002121",
language = "English",
volume = "3",
pages = "499--505",
journal = "Advances in Nutrition",
issn = "2161-8313",
publisher = "American Society for Nutrition",
number = "4",

}

TY - JOUR

T1 - Cellular Defense System Gene Expression Profiling of Human Whole Blood

T2 - Opportunities to Predict Health Benefits in Response to Diet

AU - Drew, Janice

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Diet is a critical factor in the maintenance of human cellular defense systems, immunity, inflammation, redox regulation, metabolism, and DNA repair that ensure optimal health and reduce disease risk. Assessment of dietary modulation of cellular defense systems in humans has been limited due to difficulties in accessing target tissues. Notably, peripheral blood gene expression profiles associated with nonhematologic disease are detectable. Coupled with recent innovations in gene expression technologies, gene expression profiling of human blood to determine predictive markers associated with health status and dietary modulation is now a feasible prospect for nutrition scientists. This review focuses on cellular defense system gene expression profiling of human whole blood and the opportunities this presents, using recent technological advances, to predict health status and benefits conferred by diet.

AB - Diet is a critical factor in the maintenance of human cellular defense systems, immunity, inflammation, redox regulation, metabolism, and DNA repair that ensure optimal health and reduce disease risk. Assessment of dietary modulation of cellular defense systems in humans has been limited due to difficulties in accessing target tissues. Notably, peripheral blood gene expression profiles associated with nonhematologic disease are detectable. Coupled with recent innovations in gene expression technologies, gene expression profiling of human blood to determine predictive markers associated with health status and dietary modulation is now a feasible prospect for nutrition scientists. This review focuses on cellular defense system gene expression profiling of human whole blood and the opportunities this presents, using recent technological advances, to predict health status and benefits conferred by diet.

U2 - 10.3945/an.112.002121

DO - 10.3945/an.112.002121

M3 - Article

VL - 3

SP - 499

EP - 505

JO - Advances in Nutrition

JF - Advances in Nutrition

SN - 2161-8313

IS - 4

ER -