Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study

M J Koepp, M P Richardson, D J Brooks, V J Cunningham, J S Duncan

Research output: Contribution to journalArticle

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Abstract

Previous [11C]flumazenil (FMZ) positron emission tomography (PET) investigations in patients with idiopathic generalized epilepsy (IGE) have demonstrated nonsignificant global cortical decreases in central benzodiazepine gamma-aminobutyric acid A (GABA[A]) receptor (cBZR) binding or focal decreases in the thalamus and increases in the cerebellar nuclei with no changes in cerebral cortex. We previously reported lower [11C]FMZ binding in cerebral cortex of IGE patients treated with valproate (VPA) than in cerebral cortex of controls. We now report high-resolution three-dimensional [11C]FMZ PET studies in a larger number of subjects using an improved method to detect differences in cBZR between IGE patients and controls and a more powerful longitudinal design to determine the functional effect of VPA.
Original languageEnglish
Pages (from-to)1089-97
Number of pages9
JournalEpilepsia
Volume38
Issue number10
Publication statusPublished - 1997

Fingerprint

Flumazenil
GABA Receptors
Benzodiazepines
Positron-Emission Tomography
Cerebral Cortex
Valproic Acid
Cerebellar Nuclei
Thalamus
Idiopathic Generalized Epilepsy

Keywords

  • Adult
  • Analysis of Variance
  • Brain
  • Carbon Radioisotopes
  • Cerebellum
  • Cerebral Cortex
  • Epilepsy, Generalized
  • Female
  • Flumazenil
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Receptors, GABA-A
  • Thalamus
  • Tomography, Emission-Computed
  • Valproic Acid

Cite this

Koepp, M. J., Richardson, M. P., Brooks, D. J., Cunningham, V. J., & Duncan, J. S. (1997). Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study. Epilepsia, 38(10), 1089-97.

Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study. / Koepp, M J; Richardson, M P; Brooks, D J; Cunningham, V J; Duncan, J S.

In: Epilepsia, Vol. 38, No. 10, 1997, p. 1089-97.

Research output: Contribution to journalArticle

Koepp, MJ, Richardson, MP, Brooks, DJ, Cunningham, VJ & Duncan, JS 1997, 'Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study' Epilepsia, vol. 38, no. 10, pp. 1089-97.
Koepp, M J ; Richardson, M P ; Brooks, D J ; Cunningham, V J ; Duncan, J S. / Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study. In: Epilepsia. 1997 ; Vol. 38, No. 10. pp. 1089-97.
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KW - Brain

KW - Carbon Radioisotopes

KW - Cerebellum

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KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Receptors, GABA-A

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