Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study

M J Koepp, M P Richardson, D J Brooks, V J Cunningham, J S Duncan

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Abstract

Previous [11C]flumazenil (FMZ) positron emission tomography (PET) investigations in patients with idiopathic generalized epilepsy (IGE) have demonstrated nonsignificant global cortical decreases in central benzodiazepine gamma-aminobutyric acid A (GABA[A]) receptor (cBZR) binding or focal decreases in the thalamus and increases in the cerebellar nuclei with no changes in cerebral cortex. We previously reported lower [11C]FMZ binding in cerebral cortex of IGE patients treated with valproate (VPA) than in cerebral cortex of controls. We now report high-resolution three-dimensional [11C]FMZ PET studies in a larger number of subjects using an improved method to detect differences in cBZR between IGE patients and controls and a more powerful longitudinal design to determine the functional effect of VPA.
Original languageEnglish
Pages (from-to)1089-97
Number of pages9
JournalEpilepsia
Volume38
Issue number10
Publication statusPublished - 1997

Keywords

  • Adult
  • Analysis of Variance
  • Brain
  • Carbon Radioisotopes
  • Cerebellum
  • Cerebral Cortex
  • Epilepsy, Generalized
  • Female
  • Flumazenil
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Receptors, GABA-A
  • Thalamus
  • Tomography, Emission-Computed
  • Valproic Acid

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    Koepp, M. J., Richardson, M. P., Brooks, D. J., Cunningham, V. J., & Duncan, J. S. (1997). Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study. Epilepsia, 38(10), 1089-97.